J
Jacquelyn M. Weir
Researcher at Baker IDI Heart and Diabetes Institute
Publications - 52
Citations - 3282
Jacquelyn M. Weir is an academic researcher from Baker IDI Heart and Diabetes Institute. The author has contributed to research in topics: Lipidome & Insulin resistance. The author has an hindex of 27, co-authored 52 publications receiving 2595 citations. Previous affiliations of Jacquelyn M. Weir include The Heart Research Institute & University of South Australia.
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Journal ArticleDOI
Plasma lipid profiling in a large population-based cohort
Jacquelyn M. Weir,Gerard Wong,Christopher K. Barlow,Melissa A. Greeve,Adam Kowalczyk,Laura Almasy,Anthony G. Comuzzie,Michael C. Mahaney,Jeremy B. M. Jowett,Jonathan E. Shaw,Joanne E. Curran,John Blangero,Peter J. Meikle +12 more
TL;DR: In this paper, the authors performed plasma lipid profiling using liquid chromatography electrospray ionization tandem mass spectrometry on a population cohort of more than 1,000 individuals and identified statistically significant associations of lipid classes, subclasses, and individual lipid species with anthropometric and physiological measures.
Journal ArticleDOI
Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.
John A. Bowden,Alan Heckert,Candice Z. Ulmer,Christina M. Jones,Jeremy P. Koelmel,Laila Abdullah,Linda Ahonen,Yazen Alnouti,Aaron M. Armando,John M. Asara,John M. Asara,Takeshi Bamba,John R. Barr,Jonas Bergquist,Christoph H. Borchers,Joost Brandsma,Susanne B. Breitkopf,Tomas Cajka,Amaury Cazenave-Gassiot,Antonio Checa,Michelle Cinel,Romain A. Colas,Serge Cremers,Edward A. Dennis,James E. Evans,Alexander Fauland,Oliver Fiehn,Oliver Fiehn,Michael S. Gardner,Timothy J. Garrett,Katherine H. Gotlinger,Jun Han,Yingying Huang,Aveline H. Neo,Tuulia Hyötyläinen,Yoshihiro Izumi,Hongfeng Jiang,Houli Jiang,Jiang Jiang,Maureen Kachman,Reiko Kiyonami,Kristaps Klavins,Christian Klose,Harald Köfeler,Johan Kolmert,Therese Koal,Grielof Koster,Zsuzsanna Kuklenyik,Irwin J. Kurland,Michael Leadley,Karen Lin,Krishna Rao Maddipati,Danielle J. McDougall,Peter J. Meikle,Natalie A. Mellett,Cian Monnin,M. Arthur Moseley,Renu Nandakumar,Matej Orešič,Rainey E. Patterson,David A. Peake,Jason S. Pierce,Martin Post,Anthony D. Postle,Rebecca S. Pugh,Yunping Qiu,Oswald Quehenberger,Parsram Ramrup,Jon Rees,Barbara Rembiesa,Denis Reynaud,Mary R. Roth,Susanne Sales,Kai Schuhmann,Michal L. Schwartzman,Charles N. Serhan,Andrej Shevchenko,Stephen E. Somerville,Lisa St. John-Williams,Michal A. Surma,Hiroaki Takeda,Rhishikesh Thakare,J. Will Thompson,Federico Torta,Alexander Triebl,Martin Trötzmüller,S. J. Kumari A. Ubhayasekera,Dajana Vuckovic,Jacquelyn M. Weir,Ruth Welti,Markus R. Wenk,Craig E. Wheelock,Libin Yao,Min Yuan,Xueqing Zhao,Senlin Zhou +95 more
TL;DR: The central theme of the interlaboratory study was to provide values to help harmonize lipids, lipid mediators, and precursor measurements across the community, and it was also initiated to stimulate a discussion regarding areas in need of improvement.
Journal ArticleDOI
Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
Graeme I. Lancaster,Graeme I. Lancaster,Katherine G. Langley,Katherine G. Langley,Nils A. Berglund,Helene L. Kammoun,Saskia Reibe,Emma Estevez,Jacquelyn M. Weir,Natalie A. Mellett,Gerard Pernes,James R.W. Conway,James R.W. Conway,Man K.S. Lee,Paul Timpson,Paul Timpson,Andrew J. Murphy,Andrew J. Murphy,Seth L. Masters,Seth L. Masters,Steve Gerondakis,Nenad Bartonicek,Dominik C. Kaczorowski,Marcel E. Dinger,Marcel E. Dinger,Peter J. Meikle,Peter J. Bond,Peter J. Bond,Mark A. Febbraio,Mark A. Febbraio,Mark A. Febbraio +30 more
TL;DR: It is shown that TLR4-dependent priming alters cellular metabolism, gene expression, lipid metabolic pathways, and membrane lipid composition, changes that are necessary for lcSFA-induced inflammation.
Journal ArticleDOI
Plasma Lipidomic Analysis of Stable and Unstable Coronary Artery Disease
Peter J. Meikle,Gerard Wong,Despina Tsorotes,Christopher K. Barlow,Jacquelyn M. Weir,Michael J. Christopher,Gemma L MacIntosh,Benjamin Goudey,Linda Stern,Adam Kowalczyk,Izhak Haviv,Anthony J. White,Anthony M. Dart,Stephen J. Duffy,Garry L. Jennings,Bronwyn A. Kingwell +15 more
TL;DR: Traditional risk factors for coronary artery disease (CAD) fail to adequately distinguish patients who have atherosclerotic plaques susceptible to instability from those who have more benign forms, so plasma lipid profiling may contribute to a new approach to risk stratification for unstable CAD.
Journal ArticleDOI
Plasma Lipid Profiling Shows Similar Associations with Prediabetes and Type 2 Diabetes
Peter J. Meikle,Gerard Wong,Christopher K. Barlow,Jacquelyn M. Weir,Melissa A. Greeve,Gemma L MacIntosh,Laura Almasy,Anthony G. Comuzzie,Michael C. Mahaney,Adam Kowalczyk,Izhak Haviv,Narelle Grantham,Dianna J. Magliano,Jeremy B M Jowett,Paul Zimmet,Joanne E. Curran,John Blangero,Jonathan E. Shaw +17 more
TL;DR: Lipid classes and species associated with type 2 diabetes provide support for a number of existing paradigms of dyslipidemia and suggest new avenues of investigation.