Etsuro Ogata

TL;DR: It is concluded that estrogens depress bone turnover primarily by suppressing bone resorption and, as a consequence, bone formation as well, whereas alfacalcidol “supercouples” these processes, in that it suppresses bone resOrption while maintaining or stimulating bone formation.

TL;DR: Cyclin E functions as a coactivator of the AR, and that aberrant expression of cyclin E in tumors may contribute to persistent activation of AR function, even during androgen ablation therapy.

TL;DR: The results suggest thatactive vitamin D exerts an antiosteoporotic effect by inhibiting osteoclastic bone resorption while maintaining osteoblastic function, and that these anticatabolic/anabolic effects of active vitamin D take place independently of its effects on calcium absorption and PTH.

TL;DR: It is shown that C/EBP homologous protein (CHOP) is expressed in bone as well as in mesenchymal progenitors and primary osteoblasts and may have dual roles in regulating osteoblast differentiation and bone formation.

TL;DR: It is suggested that alfacalcidol exerts bone-protective effects independently of its Ca-related effects, and is in this respect superior to vitamin D3, and that the skeletal actions of al FacalcIDol take place, at least in part, independently of suppression of PTH.