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Eugenia Trushina
Researcher at Mayo Clinic
Publications - 64
Citations - 5007
Eugenia Trushina is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Mitochondrion & Medicine. The author has an hindex of 23, co-authored 51 publications receiving 3628 citations. Previous affiliations of Eugenia Trushina include University of Rochester.
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Journal ArticleDOI
Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
Eric Tönnies,Eugenia Trushina +1 more
TL;DR: The role of oxidative stress in synaptic dysfunction in AD, innovative therapeutic strategies evolved based on a better understanding of the complexity of molecular mechanisms of AD, and the dual role ROS play in health and disease are discussed.
Journal ArticleDOI
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.
Eugenia Trushina,Roy B. Dyer,John D. Badger,Daren R. Ure,Lars Eide,Lars Eide,David Tran,Brent T. Vrieze,Valerie Legendre-Guillemin,Peter S. McPherson,Bhaskar S. Mandavilli,Bennett Van Houten,Scott Zeitlin,Mark A. McNiven,Ruedi Aebersold,Michael R. Hayden,Joseph E. Parisi,Erling Seeberg,Ioannis Dragatsis,Kelly Doyle,Anna Bender,Celin Chacko,Cynthia T. McMurray +22 more
TL;DR: Direct and functional evidence is provided that htt is involved in fast axonal trafficking in mammals and mhtt-mediated aggregation sequesters htt and components of trafficking machinery leading to loss of mitochondrial motility and eventual mitochondrial dysfunction.
Journal ArticleDOI
Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases
TL;DR: This review discusses similarities among HD, Friedreich ataxia and xeroderma pigmentosum, which provide insight into shared mechanisms of neuronal death, and focuses on Huntington's disease.
Journal ArticleDOI
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
Stephen C. Cunnane,Eugenia Trushina,Cecilie Morland,Alessandro Prigione,Gemma Casadesus,Zane B. Andrews,M. Flint Beal,Linda H. Bergersen,Roberta Diaz Brinton,Suzanne M. de la Monte,Anne Eckert,Jenni Harvey,Ross Jeggo,Jack H. Jhamandas,Oliver Kann,Clotilde Mannoury la Cour,William Martin,Gilles Mithieux,Paula I. Moreira,Michael P. Murphy,Klaus-Armin Nave,Tal Nuriel,Stéphane H. R. Oliet,Stéphane H. R. Oliet,Frédéric Saudou,Frédéric Saudou,Mark P. Mattson,Russell H. Swerdlow,Millan Mark +28 more
TL;DR: The approaches described include restoring oxidative phosphorylation and glycolysis, increasing insulin sensitivity, correcting mitochondrial dysfunction, ketone-based interventions, acting via hormones that modulate cerebral energetics, RNA therapeutics and complementary multimodal lifestyle changes.
Journal ArticleDOI
Identification of Altered Metabolic Pathways in Plasma and CSF in Mild Cognitive Impairment and Alzheimer’s Disease Using Metabolomics
TL;DR: Global metabolic changes in plasma and cerebrospinal fluid from the same individuals with different AD severity are determined and metabolomics could advance the understanding of the early disease mechanisms shared in progression from CN to MCI and to AD.