E
Eva d'Hennezel
Researcher at McGill University
Publications - 20
Citations - 2417
Eva d'Hennezel is an academic researcher from McGill University. The author has contributed to research in topics: FOXP3 & IL-2 receptor. The author has an hindex of 14, co-authored 20 publications receiving 1846 citations. Previous affiliations of Eva d'Hennezel include McGill University Health Centre & University of British Columbia.
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Journal ArticleDOI
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
Tommi Vatanen,Tommi Vatanen,Aleksandar Kostic,Aleksandar Kostic,Eva d'Hennezel,Heli Siljander,Eric A. Franzosa,Eric A. Franzosa,Moran Yassour,Raivo Kolde,Hera Vlamakis,Timothy D. Arthur,Anu Maaria Hämäläinen,Aleksandr Peet,Vallo Tillmann,Raivo Uibo,Sergei Mokurov,Natalya Dorshakova,Jorma Ilonen,Jorma Ilonen,Suvi M. Virtanen,Suvi M. Virtanen,Susanne J. Szabo,Jeffrey A. Porter,Harri Lähdesmäki,Curtis Huttenhower,Curtis Huttenhower,Dirk Gevers,Thomas W. Cullen,Mikael Knip,Ramnik J. Xavier +30 more
TL;DR: It is shown that Bacteroides LPS is structurally distinct from E. coli LPS and inhibits innate immune signaling and endotoxin tolerance, and that early colonization by immunologically silencing microbiota may preclude aspects of immune education.
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Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation
Marta Wlodarska,Chengwei Luo,Raivo Kolde,Eva d'Hennezel,John W. Annand,Cortney E. Heim,Cortney E. Heim,Philipp Krastel,Esther K. Schmitt,Abdifatah S. Omar,Elizabeth A. Creasey,Ashley L. Garner,Sina Mohammadi,Daniel J. O’Connell,Sahar Abubucker,Timothy D. Arthur,Eric A. Franzosa,Curtis Huttenhower,Curtis Huttenhower,Leon Murphy,Henry J. Haiser,Hera Vlamakis,Jeffrey A. Porter,Ramnik J. Xavier,Ramnik J. Xavier +24 more
TL;DR: The data suggest that stimulating IA production could promote anti-inflammatory responses and have therapeutic benefits, and the genetic capability of microbes to utilize mucins and metabolize tryptophan is diminished in IBD patients.
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Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling
TL;DR: This study shows that an important proinflammatory pathway that is commonly triggered by pathogenic bacteria upon interaction with the host is, in fact, actively repressed by the bacteria of the gut microbiome, supporting the idea that beneficial microbes themselves contribute to the immune tolerance in support of homeostasis.
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Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.
TL;DR: This study demonstrates that Foxp3-expressing nT Reg cells in NOD mice regulate diabetogenesis, but temporal alterations in nTreg cell function promote immune dysregulation and the onset of spontaneous autoimmunity.
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The immunogenetics of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome.
TL;DR: The genetic, immunological and clinical characteristics of IPEX syndrome are described, and the impact of heritable mutations on the function of Treg cells highlighted.