Petrozavodsk State University

About: Petrozavodsk State University is a education organization based out in Petrozavodsk, Russia. It is known for research contribution in the topics: Population & The Internet. The organization has 1182 authors who have published 1426 publications receiving 9470 citations. The organization is also known as: PetrSU.

Electrical switching and Mott transition in VO2

Abstract: In this paper the problem of the Mott metal-insulator transition in vanadium dioxide driven by an external electric field is considered. Delay time (td) measurements have shown that the experimental value of td is almost three orders of magnitude lower than the theoretical value, calculated in a simple electrothermal model. This suggests that under non-equilibrium conditions (in high electric fields) electron correlation effects contribute to the development of the insulator to metal transition. The extra-carrier injection from Si into VO2 was carried out in the structures Si-SiO2-VO2 on p-type silicon with ρ = 0.1 Ω cm and a SiO2 thickness 70 nm. It has been shown that the metal-insulator transition in VO2 can be initiated by injection, i.e. by the increase of the electron density. The value of the critical density was found to be of the order of the electron density in VO2 in the semiconducting phase, approximately 1018-1019 cm-3. This confirms that the metal-insulator transition in VO2 is the purely electronic Mott-Hubbard transition.

Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death

Abstract: Stimulator of interferon genes (STING) was initially described as a sensor of intracellular bacterial and viral DNA and a promising adjuvant target in innate immune cells; more recently STING has also been shown to detect endogenous DNA and play a role in tumor immunity and autoimmune disease development. Thus far STING has been studied in macrophages and dendritic cells. In this study, to our knowledge we provide the first evidence of STING activation in T cells, in which STING agonists not only provoke type I IFN production and IFN-stimulated gene expression, mirroring the response of innate cells, but are also capable of activating cell stress and death pathways. Our results suggest a re-evaluation of STING agonist-based therapies may be necessary to identify the possible effects on the T cell compartment. Conversely, the effects of STING on T cells could potentially be harnessed for therapeutic applications.