Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
Tommi Vatanen,Tommi Vatanen,Aleksandar Kostic,Aleksandar Kostic,Eva d'Hennezel,Heli Siljander,Eric A. Franzosa,Eric A. Franzosa,Moran Yassour,Raivo Kolde,Hera Vlamakis,Timothy D. Arthur,Anu Maaria Hämäläinen,Aleksandr Peet,Vallo Tillmann,Raivo Uibo,Sergei Mokurov,Natalya Dorshakova,Jorma Ilonen,Jorma Ilonen,Suvi M. Virtanen,Suvi M. Virtanen,Susanne J. Szabo,Jeffrey A. Porter,Harri Lähdesmäki,Curtis Huttenhower,Curtis Huttenhower,Dirk Gevers,Thomas W. Cullen,Mikael Knip,Ramnik J. Xavier +30 more
TLDR
It is shown that Bacteroides LPS is structurally distinct from E. coli LPS and inhibits innate immune signaling and endotoxin tolerance, and that early colonization by immunologically silencing microbiota may preclude aspects of immune education.About:
This article is published in Cell.The article was published on 2016-05-05 and is currently open access. It has received 879 citations till now. The article focuses on the topics: Microbiome & Hygiene hypothesis.read more
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Current understanding of the human microbiome.
Jack A. Gilbert,Jack A. Gilbert,Jack A. Gilbert,Martin J. Blaser,J. Gregory Caporaso,Janet K. Jansson,Susan V. Lynch,Rob Knight +7 more
TL;DR: This review focuses on studies in humans to describe challenges and propose strategies that leverage existing knowledge to move rapidly from correlation to causation and ultimately to translation into therapies.
Journal ArticleDOI
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota
Christian Milani,Sabrina Duranti,Francesca Bottacini,Eoghan Casey,Francesca Turroni,Jennifer Mahony,Clara Belzer,Susana Delgado Palacio,Silvia Arboleya Montes,Leonardo Mancabelli,Gabriele Andrea Lugli,Juan M. Rodríguez,Lars Bode,Willem M. de Vos,Willem M. de Vos,Miguel Gueimonde,Abelardo Margolles,Douwe van Sinderen,Marco Ventura +18 more
TL;DR: The infant microbiota, the mechanisms that drive its establishment and composition, and how microbial consortia may be molded by natural or artificial interventions are described and the relevance of key microbial players of the infant gut microbiota, in particular bifidobacteria, with respect to their role in health and disease are discussed.
Journal ArticleDOI
Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization.
Tao Zuo,Fen Zhang,Grace Lui,Yun Kit Yeoh,Amy Li,Hui Zhan,Yating Wan,Arthur C.K. Chung,Chun Pan Cheung,Nan Chen,Christopher K C Lai,Zigui Chen,Eugene Y.K. Tso,Kitty S. C. Fung,Veronica L. Chan,Lowell Ling,Gavin M. Joynt,David S.C. Hui,Francis K.L. Chan,Paul K.S. Chan,Siew C. Ng +20 more
TL;DR: Fecal microbiota alterations were associated with fecal levels of SARS-CoV-2 and COVID-19 severity, and strategies to alter the intestinal microbiota might reduce disease severity.
Journal ArticleDOI
Dysbiosis and the immune system
TL;DR: This Review categorizes dysbiosis in conceptual terms and provides an overview of immunological associations; the causes and consequences of bacterial Dysbiosis, and their involvement in the molecular aetiology of common diseases; and implications for the rational design of new therapeutic approaches.
Journal ArticleDOI
Signals from the gut microbiota to distant organs in physiology and disease
TL;DR: This Review will discuss microbiota–host cross-talk and intestinal microbiome signaling to extraintestinal organs, and review mechanisms of how this communication might contribute to host physiology and discuss how misconfigured signaling may contribute to different diseases.
References
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Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Harry Sokol,Bénédicte Pigneur,Laurie Watterlot,Omar Lakhdari,Luis G. Bermúdez-Humarán,Jean-Jacques Gratadoux,Sébastien Blugeon,Chantal Bridonneau,Jean-Pierre Furet,Gérard Corthier,Corinne Grangette,Nadia Vasquez,Philippe Pochart,Germain Trugnan,Ginette Thomas,Hervé M. Blottière,Joël Doré,Philippe Marteau,Philippe Seksik,Philippe Langella +19 more
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
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The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
TL;DR: This review examines the evidence in support of the hygiene hypothesis and offers a number of mechanisms that could explain the relation between sanitary conditions and susceptibility to allergic and autoimmune diseases.
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Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life.
Fredrik Bäckhed,Fredrik Bäckhed,Josefine Roswall,Yangqing Peng,Qiang Feng,Huijue Jia,Petia Kovatcheva-Datchary,Yin Li,Yan Xia,Hailiang Xie,Huanzi Zhong,Muhammad Tanweer Khan,Jianfeng Zhang,Junhua Li,Liang Xiao,Jumana Y. Al-Aama,Dongya Zhang,Ying Shiuan Lee,Dorota Ewa Kotowska,Camilla Colding,Valentina Tremaroli,Ye Yin,Stefan Bergman,Xun Xu,Lise Madsen,Lise Madsen,Karsten Kristiansen,Jovanna Dahlgren,Jun Wang +28 more
TL;DR: The gut microbiota of infants delivered by C-section showed significantly less resemblance to their mothers and nutrition had a major impact on early microbiota composition and function, with cessation of breast-feeding, rather than introduction of solid food, being required for maturation into an adult-like microbiota.
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Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
Xochitl C. Morgan,Timothy L. Tickle,Timothy L. Tickle,Harry Sokol,Harry Sokol,Dirk Gevers,Kathryn L. Devaney,Doyle V. Ward,Joshua A Reyes,Samir A. Shah,Neal Leleiko,Scott B. Snapper,Athos Bousvaros,Joshua R. Korzenik,Joshua R. Korzenik,Bruce E. Sands,Ramnik J. Xavier,Ramnik J. Xavier,Curtis Huttenhower,Curtis Huttenhower +19 more
TL;DR: The microbiome of ileal Crohn's disease was notable for increases in virulence and secretion pathways, and the first insights into community-wide microbial processes and pathways that underpin IBD pathogenesis are provided.
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Succession of microbial consortia in the developing infant gut microbiome
Jeremy E. Koenig,Aymé Spor,Nicholas B. Scalfone,Ashwana D. Fricker,Jesse Stombaugh,Rob Knight,Largus T. Angenent,Ruth E. Ley +7 more
TL;DR: This study revealed that seemingly chaotic shifts in the microbiome are associated with life events; however, additional experiments ought to be conducted to assess how different infants respond to similar life events.
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