F. Ivy Carroll

TL;DR: 3α-(4-Methylphenyl)nortropane-2β-carboxylic acid methyl ester (4c) was found to be selective and highly potent for the norepinephrine transporter (NET) relative to the dopamine and serotonin transporters.

TL;DR: The order of potencies found for the three cocaine analogs on mesencephalic cultures was similar to that previously obtained in [3H] WIN 35,428 binding experiments, suggesting that the pharmacological selectivity of cocaine sites functionally related to the DA transporter in cultured embryonic neurons does not differ from that obtained in adult rat brain.

TL;DR: Alkylation of 2-chloro-N,N-dimethylpropylamine with the lithium salt derived from 2-(p-methoxyphenyl)-2-phenylacetonitrile 1 afforded a mixture of p-methyloxymethadone nitrile 3 and pmethoxyisomethadone nitrizone 4 The nitriles were separated chromatographically and the amino nitrizle 3 was converted subsequently into the diastereoisomeric p-hydroxymethaddone 8 hydrochlorides Careful rec

TL;DR: In this article, a radiotracer was prepared by N-benzylation of (+)-cis-N-normetazocine with [α-11C]-benzmanyl iodide in ethanol using sodium hydrogen carbonate as the proton acceptor.

TL;DR: A new chiral synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (2, J-113397) was developed.