F
F. Ivy Carroll
Researcher at Research Triangle Park
Publications - 301
Citations - 11139
F. Ivy Carroll is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Nicotinic agonist & Dopamine transporter. The author has an hindex of 52, co-authored 301 publications receiving 10411 citations. Previous affiliations of F. Ivy Carroll include RTI International & St. Joseph's Hospital and Medical Center.
Papers
More filters
Journal ArticleDOI
3′-Fluoro substitution in the pyridine ring of epibatidine improves selectivity and efficacy for α4β2 versus α3β4 nAChRs
Galya R. Abdrakhmanova,Galya R. Abdrakhmanova,F. Ivy Carroll,F. Ivy Carroll,M I Damaj,M I Damaj,Billy R. Martin,Billy R. Martin +7 more
TL;DR: The 3′-fluoro substituent at the 3′ position of the pyridine ring of epibatidine has been recently developed and shown to possess binding affinity in the pM range to α4β2 nAChRs and in the nM ranges to α7 nACHRs and to exhibit potent agonist activity in nicotine-induced analgesia tests.
Journal ArticleDOI
Synthesis and structure―activity relationship of 3β-(4-alkylthio, - methylsulfinyl, and -methylsulfonylphenyl)tropane and 3β-(4-alkylthiophenyl)nortropane derivatives for monoamine transporters
TL;DR: None of the compounds showed selectivity similar to 5 for both the DAT and 5-HTT relative to the NET, but the 3beta-(4-methylthiophenyl)tropane 7a and its N-(3-fluoropropyl) analogue 9a and N-allyl analogue 10a are the most selective compounds for the 5- HTT over the NET.
Journal ArticleDOI
An Improved Synthesis of (3R)-2-(tert-Butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid
TL;DR: An improved synthesis of (3 R)-2-(TERT-butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is described in this paper, where a modified Pictet-Spengler reaction was employed to provide 95% yield of the product with 7% racemization or less.
Journal ArticleDOI
Synthesis and Evaluation of Metabotropic Glutamate Receptor Subtype 5 Antagonists Based on Fenobam().
Moses G. Gichinga,Jeremy P. Olson,Elizabeth Butala,Hernán A. Navarro,Brian P. Gilmour,S. Wayne Mascarella,F. Ivy Carroll +6 more
TL;DR: In an effort to discover potent and selective metabotropic glutamate receptor subtype 5 (mGluR5) antagonists, 15 tetrahydropyrimidinone analogues of 1-(3-chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)-urea (fenobam) were synthesized.
Journal ArticleDOI
Carbon-13 nuclear magnetic resonance spectra of 5-alkyl-5-(1-methylbutyl)barbituric acids
TL;DR: In this paper, the natural-abundance 13C n.m.r. spectra of 5-alkyl-5-(1-methylbutyl) barbituric acids have been obtained.