F
F. Ivy Carroll
Researcher at Research Triangle Park
Publications - 301
Citations - 11139
F. Ivy Carroll is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Nicotinic agonist & Dopamine transporter. The author has an hindex of 52, co-authored 301 publications receiving 10411 citations. Previous affiliations of F. Ivy Carroll include RTI International & St. Joseph's Hospital and Medical Center.
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Journal ArticleDOI
Synthesis and stereoselective reduction of (±)-, (+)- and (–)-6-substituted-6-azabicyclo[3.2.1]octan-3-one
TL;DR: In this paper, a three-step general synthetic route to both racemic and optically active 6-substituted 6-azabicyclo[321]octan-3-ones has been developed.
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Design, Synthesis, and Biological Evaluation of Structurally Rigid Analogues of 4-(3-Hydroxyphenyl)piperidine Opioid Receptor Antagonists.
Scott P. Runyon,Chad M. Kormos,Moses G. Gichinga,S. Wayne Mascarella,Hernán A. Navarro,Jeffrey R. Deschamps,Gregory H. Imler,F. Ivy Carroll +7 more
TL;DR: Evaluation of the conformationally constrained series showed that structural rigid compounds having the 3-hydroxyphenyl group locked in the piperidine equatorial orientation had potencies equal to or better than similar compounds having more flexible structures similar to 1.1.0.
Journal ArticleDOI
Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice.
Richard B. Rothman,F. Ivy Carroll,Marisela Morales,Daniel L. Rowley,Kenner C. Rice,Christina M. Dersch,David M. Donovan +6 more
TL;DR: The relatively high density of site “X” in brain membranes and the fact that the Ki values of cocaine and cocaethylene for site ‘X�’ are in the range achieved in the brain following cocaine administration suggests that site ’X’ could contribute to the pharmacological or toxicological effects of cocaine.
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Synthesis, structural identification, and ligand binding of tropane ring analogs of paroxetine and an unexpected aza-bicyclo[3.2.2]nonane rearrangement product.
Scott P. Runyon,Jason P. Burgess,Philip Abraham,Kathryn I. Keverline-Frantz,J. L. Flippen-Anderson,Jeffrey R. Deschamps,Anita H. Lewin,Hernán A. Navarro,John W. Boja,Michael J. Kuhar,F. Ivy Carroll +10 more
TL;DR: The structural requirements for high affinity at the serotonin transporter (5-HTT) have been investigated through the preparation of rigid paroxetine analogs and nucleophilic addition to the intermediate 2beta-methanesulfonyloxymethyl-3beta-(4-fluorophenyl)tropane unexpectedly provided the aza-bicyclo[3.2.2]nonane derivative 10a.
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The κ-opioid receptor antagonist JDTic decreases ethanol intake in alcohol-preferring AA rats.
Johanna Uhari-Väänänen,Johanna Uhari-Väänänen,Atso Raasmaja,Pia Bäckström,Ville Oinio,Ville Oinio,F. Ivy Carroll,Mikko Airavaara,Kalervo Kiianmaa,Petteri Piepponen +9 more
TL;DR: It is suggested that κ-opioid receptor antagonists may be a valuable adjunct in the pharmacotherapy of ethanol use disorders and that accumbal λ-opIOid receptors participate in the modulation of the reinforcing effects of ethanol.