F
F. Ivy Carroll
Researcher at Research Triangle Park
Publications - 301
Citations - 11139
F. Ivy Carroll is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Nicotinic agonist & Dopamine transporter. The author has an hindex of 52, co-authored 301 publications receiving 10411 citations. Previous affiliations of F. Ivy Carroll include RTI International & St. Joseph's Hospital and Medical Center.
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Journal ArticleDOI
Nicotinic acetylcholine receptor efficacy and pharmacological properties of 3-(substituted phenyl)-2β-substituted tropanes.
F. Ivy Carroll,Bruce E. Blough,S. Wayne Mascarella,Hernán A. Navarro,J. Brek Eaton,Ronald J. Lukas,M. Imad Damaj +6 more
TL;DR: Several new 3-phenyltropane analogues that are superior to 2 in inhibition of dopamine, norepinephrine, and sometimes serotonin reuptake are identified that have utility as research tools and possible promise for treatment of nicotine dependence.
Journal ArticleDOI
Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3R)-7-Hydroxy-N-[(1S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic)
Pauline W. Ondachi,Chad M. Kormos,Scott P. Runyon,James B. Thomas,S. Wayne Mascarella,Ann M. Decker,Hernán A. Navarro,Timothy R. Fennell,Rodney W. Snyder,F. Ivy Carroll +9 more
TL;DR: Calculated log BB and CNS (central nervous system) multiparameter optimization (MPO) and low molecular weight values all predict that 12 will penetrate the brain, and pharmacokinetic studies in rats show that 12 does indeed penetrated the brain.
Journal ArticleDOI
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres.
Chad M. Kormos,Moses G. Gichinga,Scott P. Runyon,James B. Thomas,S. Wayne Mascarella,Ann M. Decker,Hernán A. Navarro,F. Ivy Carroll +7 more
TL;DR: Of the JDTic analogs, (3R)-7-hydroxy-N-(1S)-2-methyl-[4-methyl-4-pyridine-3-yl-carboxamide (3b)) had the best overall binding potency and selectivity in a [(35)S]GTPγS functional assay, and Calculated physiochemical properties for 3b suggest that it will cross the blood-brain barrier.
Journal ArticleDOI
Synthesis and Monoamine Transporter Binding Properties of 2,3-Diaryltropanes
Sharadsrikar V Kotturi,Songchun Jiang,An-Chih Chang,Philip Abraham,Hernán A. Navarro,Michael J. Kuhar,F. Ivy Carroll +6 more
TL;DR: The results showed that the replacement of the 2 beta-carbomethoxy group in the 3-aryltropane class with a 2beta-aryl group led to compounds possessing very similar monoamine transporter binding properties, however, the 2beta,3beta-diaryltropanes tended to be more potent at the DAT and more selective for theDAT relative to the NET and 5-HTT.
Journal ArticleDOI
4β-Methyl-5-(3-hydroxyphenyl)morphan opioid agonist and partial agonist derived from a 4β-methyl-5-(3-hydroxyphenyl)morphan pure antagonist.
F. Ivy Carroll,Moses G. Gichinga,John D. Williams,Eyal Vardy,Bryan L. Roth,S. Wayne Mascarella,James B. Thomas,Hernán A. Navarro +7 more
TL;DR: It is reported that addition of a 7 α-amino, 7α-alkylamino, or7α-dialkylamino group to 4 leads to opioid ligands that are largely μ or δ agonist with mixed agonist/antagonist properties.