F
F. Ivy Carroll
Researcher at Research Triangle Park
Publications - 301
Citations - 11139
F. Ivy Carroll is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Nicotinic agonist & Dopamine transporter. The author has an hindex of 52, co-authored 301 publications receiving 10411 citations. Previous affiliations of F. Ivy Carroll include RTI International & St. Joseph's Hospital and Medical Center.
Papers
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Journal ArticleDOI
Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model
Shakir D. AlSharari,Shakir D. AlSharari,Deniz Bagdas,Deniz Bagdas,Hamid I. Akbarali,Patraic A. Lichtman,Erinn S. Raborn,Guy A. Cabral,F. Ivy Carroll,Elizabeth A. McGee,M. Imad Damaj +10 more
TL;DR: The results show for the first time that female mice are less sensitive to the anti-colitis activity of α7 agonists, suggesting that targeting α7 nAChRs could represent a viable therapeutic approach for intestinal inflammation diseases with the consideration of sex differences.
Journal ArticleDOI
Synthesis and cocaine receptor affinities of 3-phenyl-2-(3′-methyl-1,2,4-oxadiazole-5′-yl)tropane isomers
F. Ivy Carroll,Philip Abraham,Michael Kuzemko,J. L. Gray,Anita H. Lewin,John W. Boja,Michael J. Kuhar +6 more
TL;DR: In this paper, the synthesis and binding affinities at the cocaine receptor of all four isomers of 3-phenyl-2-(3-methyl-1,2,4-oxadiazole-5-yl)tropane derivable from natural (−)-cocaine were reported.
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Discovery of the First N-Substituted 4β-Methyl-5-(3-hydroxyphenyl)morphan To Possess Highly Potent and Selective Opioid δ Receptor Antagonist Activity
F. Ivy Carroll,Li Zhang,S. Wayne Mascarella,Hernán A. Navarro,Richard B. Rothman,Buddy E. Cantrell,and Dennis M. Zimmerman,James B. Thomas +7 more
TL;DR: To the authors' knowledge, this is the first potent and selective δ opioid receptor antagonist from the 5-phenylmorphan class of opioids.
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Studies of the biogenic amine transporters. VIII: identification of a novel partial inhibitor of dopamine uptake and dopamine transporter binding.
TL;DR: The present results indicate that SoRI‐9804 discriminates two components of the DA transporter, and it is needed to determine the underlying mechanism of this effect and if partial inhibition of DA uptake results in any unique behavioral effects.
Journal ArticleDOI
Novel Synthesis and Pharmacological Characterization of NOP Receptor Agonist 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198).
Steven D. Chang,Lawrence E. Brieaddy,Joseph D. Harvey,Anita H. Lewin,S. Wayne Mascarella,Herbert H. Seltzman,P. Anantha Reddy,Ann M. Decker,Charles J. McElhinny,Desong Zhong,Elisha E. Peterson,Hernán A. Navarro,Michael R. Bruchas,F. Ivy Carroll +13 more
TL;DR: A more efficient and convenient method of synthesis is detailed, and both in vitro and in vivo pharmacological assays are used to fully characterize this ligand, providing additional insights into the useful, systemically active, NOP receptor agonist Ro 64-6198.