F
F. Ivy Carroll
Researcher at Research Triangle Park
Publications - 301
Citations - 11139
F. Ivy Carroll is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Nicotinic agonist & Dopamine transporter. The author has an hindex of 52, co-authored 301 publications receiving 10411 citations. Previous affiliations of F. Ivy Carroll include RTI International & St. Joseph's Hospital and Medical Center.
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Journal ArticleDOI
Locomotor stimulant effects of novel phenyltropanes in the mouse
TL;DR: Each analog was more potent than cocaine in the in vivo assay, as observed in the earlier in vitro studies, and several compounds exhibited properties ideal for medications for cocaine abusers, such as an equivalent efficacy, a higher potency, and a longer duration of action as compared to cocaine.
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Lack of dopamine receptor agonists effect on striatal dopamine transporter binding sites.
TL;DR: Analysis of the results indicated that quinpirole and apomorphine administration did not alter DAT cocaine binding sites, suggesting that cocaine-induced-upregulation in DAT binding sites is through stimulation of presynaptic D2 receptors by excess synaptic dopamine.
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In vitro and in vivo characterization of a novel negative allosteric modulator of neuronal nAChRs.
Galya R. Abdrakhmanova,Bruce E. Blough,Carey Nesloney,Hernán A. Navarro,M. Imad Damaj,F. Ivy Carroll +5 more
TL;DR: In vitro and in vivo data suggest that HDMP is a novel NAM of neuronal nAChRs with potent inhibitory activity at α7 nAHydro-2-benzyl-6-N,N-dimethylamino-1-methylindeno[1,2,-b]pyrrole at concentrations ≤ 1μM that are not effective for α4β2 and α3β4 nA ChRs.
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The Discovery and Development of the N‐Substituted trans‐3,4‐Dimethyl‐4‐(3′‐hydroxyphenyl)piperidine Class of Pure Opioid Receptor Antagonists
F. Ivy Carroll,Roland E. Dolle +1 more
TL;DR: This review describes the discovery and development of the potent and selective κ opioid receptor antagonist JDTic and analogues as potential pharmacotherapies for treating depression, anxiety, and substance abuse (nicotine, alcohol, and cocaine).
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Synthesis and Structural Determination of 5H-Benzocyclohepten-5,8-imines
TL;DR: In this article, 4-hydroxy-N-methylisoquinolinium iodide with triethylamine in tetrahydrofuran or acetonitrile forms 2-methyl-4-oxidoisoquinium (2) in situ.