F
Fabienne Picard
Researcher at Geneva College
Publications - 114
Citations - 4482
Fabienne Picard is an academic researcher from Geneva College. The author has contributed to research in topics: Epilepsy & Nicotinic agonist. The author has an hindex of 33, co-authored 111 publications receiving 3969 citations. Previous affiliations of Fabienne Picard include University of Bern & University of Geneva.
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Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations
Stéphanie Baulac,Saeko Ishida,Elise Marsan,Catherine Miquel,Arnaud Biraben,Dang Khoa Nguyen,Doug Nordli,Patrick Cossette,Sylvie Nguyen,Virginie Lambrecq,Mihaela Vlaicu,Mailys Daniau,Franck Bielle,Eva Andermann,Eva Andermann,Frederick Andermann,Frederick Andermann,Eric LeGuern,Francine Chassoux,Fabienne Picard +19 more
TL;DR: The role of DEPDC5 is extended to focal cortical dysplasias (FCDs) in familial focal epilepsies by extending the role of mTORC1 repressor toDEP domain‐containing protein 5.
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Mutations of DEPDC5 cause autosomal dominant focal epilepsies
Saeko Ishida,Fabienne Picard,Gabrielle Rudolf,Eric Noé,Eric Noé,Guillaume Achaz,Guillaume Achaz,Guillaume Achaz,Pierre Thomas,Pierre Genton,Emeline Mundwiller,Markus Wolff,Christian Marescaux,Richard B. Miles,Richard B. Miles,Michel Baulac,Michel Baulac,Edouard Hirsch,Eric LeGuern,Eric LeGuern,Stéphanie Baulac,Stéphanie Baulac +21 more
TL;DR: These findings provided evidence of frequent (37%) loss-of-function mutations in DEPDC5 associated with a broad spectrum of focal epilepsies and the implication of a DEP domain–containing protein that may be involved in membrane trafficking and/or G protein signaling opens new avenues for research.
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A Second Locus for Familial Generalized Epilepsy with Febrile Seizures Plus Maps to Chromosome 2q21-q33
Stéphanie Baulac,Isabelle Gourfinkel-An,Fabienne Picard,Fabienne Picard,Myriam Rosenberg-Bourgin,Jean-François Prud'homme,Michel Baulac,Alexis Brice,Eric LeGuern +8 more
TL;DR: A clinical and genetic study of a family with a phenotype resembling generalized epilepsy with febrile seizures plus (GEFS+), described by Berkovic and colleagues, finds four genes coding for different isoforms of the alpha-subunit voltage-gated sodium channels located in this region are strong candidates for the disease gene.
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Nocturnal Hypermotor Seizures, Suggesting Frontal Lobe Epilepsy, Can Originate in the Insula
Philippe Ryvlin,Lorella Minotti,Geneviève Demarquay,Edouard Hirsch,Alexis Arzimanoglou,Dominique Hoffman,Marc Guénot,Fabienne Picard,Sylvain Rheims,Philippe Kahane +9 more
TL;DR: Three patients with drug‐resistantNocturnal hypermotor seizures (NHSs), no detectable brain lesion, and clinically defined nocturnal frontal lobe epilepsy (NFLE) or autosomal dominant NLFE (ADNFLE), whose intracerebral EEG ictal onset primarily involved the insula, rather than the mesial or orbital frontal cortex.
Journal ArticleDOI
Definition and diagnostic criteria of sleep-related hypermotor epilepsy
Paolo Tinuper,Francesca Bisulli,JH Cross,Dale C. Hesdorffer,Philippe Kahane,Lino Nobili,Federica Provini,Ingrid E. Scheffer,Laura Tassi,Luca Vignatelli,Claudio L. Bassetti,Fabio Cirignotta,Christopher P. Derry,Antonio Gambardella,Renzo Guerrini,Péter Halász,Laura Licchetta,Mark Mahowald,Raffaele Manni,Carla Marini,Barbara Mostacci,Ilaria Naldi,Liborio Parrino,Fabienne Picard,Maura Pugliatti,Philippe Ryvlin,Federico Vigevano,Marco Zucconi,Samuel F. Berkovic,Ruth Ottman +29 more
TL;DR: It was recommended that the name be changed to sleep-related hypermotor epilepsy (SHE), reflecting evidence that the attacks are associated with sleep rather than time of day, the seizures may arise from extrafrontal sites, and the motor aspects of the seizures are characteristic.