Fardous F. El-Senduny

TL;DR: Electronic databases were extensively searched and results showed that curcumin exerts remarkable protective and therapeutic effects of oxidative associated liver diseases through various cellular and molecular mechanisms.

TL;DR: The neuroprotective effects of naringenin, as well as its related pharmacological targets, signaling pathways, molecular mechanisms, and clinical perspective, are described and the need to develop novel naringanin delivery systems is discussed to solve its widespread pharmacokinetic limitation.

TL;DR: Compound 4k proved to retain a high cytotoxic activity and selectivity against colon cancer cells HCT-116, hepatocellular carcinoma, and prostate cancer cells PC-3 in comparison to cisplatin, and ligand Efficiency and Ligand Lipophilic Efficiency were evaluated and revealed that compound 4k had acceptable value.

TL;DR: Cucurbitacin B is a promising chemosensitizer for the cisplatin-resistant ovarian cancer and shows cytotoxicity against the ovarian cancer cell lines, and pretreatment of A2780CP cells leads to a significant increase in the cytotoxic effect of cisPlatin.

TL;DR: A one-pot three-component reaction via a [3 + 2] cycloaddition/ring contraction sequence of a dipolarophile (activated alkene) with in situ-generated azomethine ylide (1,3-dipoles) without the use of any catalyst provides efficient access to synthetically useful and biologically important spirooxindoles in high yield with high diastereoselectivity.