Institution
Military University Nueva Granada
Education•Bogotá, Colombia•
About: Military University Nueva Granada is a education organization based out in Bogotá, Colombia. It is known for research contribution in the topics: Population & Medicine. The organization has 3102 authors who have published 3433 publications receiving 13265 citations.
Topics: Population, Medicine, Context (language use), Politics, Corrosion
Papers published on a yearly basis
Papers
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TL;DR: Electronic databases were extensively searched and results showed that curcumin exerts remarkable protective and therapeutic effects of oxidative associated liver diseases through various cellular and molecular mechanisms.
Abstract: Oxidative stress has been considered a key causing factor of liver damage induced by a variety of agents, including alcohol, drugs, viral infections, environmental pollutants and dietary components, which in turn results in progression of liver injury, non-alcoholic steatohepatitis, non-alcoholic liver disease, liver fibrosis and cirrhosis. During the past 30 years and even after the major progress in the liver disease management, millions of people worldwide still suffer from an acute or chronic liver condition. Curcumin is one of the most commonly used indigenous molecules endowed by various shielding functionalities that protects the liver. The aim of the present study is to comprehensively review pharmacological effects and molecular mechanisms, as well as clinical evidence, of curcumin as a lead compound in the prevention and treatment of oxidative associated liver diseases. For this purpose, electronic databases including “Scopus,” “PubMed,” “Science Direct” and “Cochrane library” were extensively searched with the keywords “curcumin or curcuminoids” and “hepatoprotective or hepatotoxicity or liver” along with “oxidative or oxidant.” Results showed that curcumin exerts remarkable protective and therapeutic effects of oxidative associated liver diseases through various cellular and molecular mechanisms. Those mechanisms include suppressing the proinflammatory cytokines, lipid perodixation products, PI3K/Akt and hepatic stellate cells activation, as well as ameliorating cellular responses to oxidative stress such as the expression of Nrf2, SOD, CAT, GSH, GPx and GR. Taking together, curcumin itself acts as a free radical scavenger over the activity of different kinds of ROS via its phenolic, β-diketone and methoxy group. Further clinical studies are still needed in order to recognize the structure-activity relationships and molecular mechanisms of curcumin in oxidative associated liver diseases.
231 citations
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TL;DR: The aim of this study was to determine the distribution of Blastocystis STs in different Colombian hosts and to expand on the phylogeographic differences observed so far with a view to exploring and understanding host-parasite co-evolution.
196 citations
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Paris Descartes University1, Leiden University Medical Center2, Ghent University Hospital3, Military University Nueva Granada4, National Autonomous University of Mexico5, Cordoba University6, Oregon Health & Science University7, Cairo University8, Russian Academy of Sciences9, Sun Yat-sen University10, Hanyang University11, International University, Cambodia12, Chang Gung University13, University of Coimbra14, University College London15, University of Alberta16, University of Leeds17, University of Pavia18, Erciyes University19
TL;DR: Rigorous application of systematic evaluation of comorbidities may permit earlier detection of previously unknown risk factors, which may ultimately result in an improved outcome of patients with SpA.
Abstract: Background Increased risk of some comorbidities has been reported in spondyloarthritis (SpA). Recommendations for detection/management of some of these comorbidities have been proposed, and it is known that a gap exists between these and their implementation in practice. Objective To evaluate (1) the prevalence of comorbidities and risk factors in different countries worldwide, (2) the gap between available recommendations and daily practice for management of these comorbidities and (3) the prevalence of previously unknown risk factors detected as a result of the present initiative. Methods Cross-sectional international study with 22 participating countries (from four continents), including 3984 patients with SpA according to the rheumatologist. Statistical analysis The prevalence of comorbidities (cardiovascular, infection, cancer, osteoporosis and gastrointestinal) and risk factors; percentage of patients optimally monitored for comorbidities according to available recommendations and percentage of patients for whom a risk factor was detected due to this study. Results The most frequent comorbidities were osteoporosis (13%) and gastroduodenal ulcer (11%). The most frequent risk factors were hypertension (34%), smoking (29%) and hypercholesterolaemia (27%). Substantial intercountry variability was observed for screening of comorbidities (eg, for LDL cholesterol measurement: from 8% (Taiwan) to 98% (Germany)). Systematic evaluation (eg, blood pressure (BP), cholesterol) during this study unveiled previously unknown risk factors (eg, elevated BP (14%)), emphasising the suboptimal monitoring of comorbidities. Conclusions A high prevalence of comorbidities in SpA has been shown. Rigorous application of systematic evaluation of comorbidities may permit earlier detection, which may ultimately result in an improved outcome of patients with SpA.
174 citations
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TL;DR: Microstructural and mechanical properties of alkali activated binders based on blends of Colombian granulated blast furnace slag and fly ash and a sodium aluminosilicate hydrate with Al in its structure were investigated were found to be more dense and compact with almost absence of pores.
Abstract: Microstructural and mechanical properties of alkali activated binders based on blends of Colombian granulated blast furnace slag (GBFS) and fly ash (FA) were investigated. The synthesis of alkali activated binders was conducted at 85 °C for 24 h with different slag/fly ash ratios (100:0, 80:20, 60:40, 40:60, 20:80, and 0:100). Mineralogical and microstructural characterization was carried out by means of X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDX) and Nuclear magnetic resonance (NMR). Mechanical properties were evaluated through the compressive strength, modulus of elasticity and Poisson's ratio. The results show that two different reaction products were detected in the slag/fly ash mixtures, a calcium silicate hydrate with Al in its structure (C-A-S-H gel) and a sodium aluminosilicate hydrate (N-A-S-H gel) with higher number of polymerized species and low content in Ca. It was found that with the increase of the amount of added slag, the amount of C-A-S-H gel increased and the amount of N-A-S-H gel decreased. The matrix was more dense and compact with almost absence of pores. The predominance of slag affected positively the compressive strength, Young's modulus and Poisson's ratio, with 80% slag and 20% fly ash concrete being the best mechanical performance blend.
112 citations
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TL;DR: In this article, Vanadium nitride (V-N) thin films were grown using a reactive d.c. magnetron sputtering process, from a vanadium target (99.999%) in an Ar/N2 gas mixture at different deposition bias voltage.
98 citations
Authors
Showing all 3128 results
Name | H-index | Papers | Citations |
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Dietmar H. Pieper | 54 | 220 | 9034 |
Juan J. Rodriguez | 50 | 175 | 8728 |
Kris Dierickx | 42 | 225 | 6195 |
Juan David Ramírez | 34 | 188 | 4098 |
Javier Rodríguez | 34 | 173 | 3860 |
Ruy Jauregui | 29 | 79 | 2471 |
Carlos Díaz | 28 | 96 | 5835 |
Ramiro Vilchez-Vargas | 26 | 63 | 1912 |
Sergio Mora | 26 | 94 | 2744 |
Howard Junca | 25 | 75 | 1872 |
Marcus Tullius Scotti | 24 | 242 | 2369 |
Jaime Soto | 23 | 33 | 2080 |
Paul A. Camacho | 20 | 85 | 1083 |
Juan Ruiz | 19 | 41 | 1386 |
John Londoño | 18 | 114 | 1172 |