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Fatma Ahmet
Researcher at Monash University
Publications - 11
Citations - 1140
Fatma Ahmet is an academic researcher from Monash University. The author has contributed to research in topics: Antigen & Antigen presentation. The author has an hindex of 7, co-authored 11 publications receiving 1035 citations. Previous affiliations of Fatma Ahmet include Burnet Institute & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
The dendritic cell subtype restricted C-type lectin Clec9A is a target for vaccine enhancement
Irina Caminschi,Anna I Proietto,Fatma Ahmet,Susie Kitsoulis,Joo Shin Teh,Jennifer Chi Yi Lo,Alexandra Rizzitelli,Li Wu,David Vremec,Serani Lh van Dommelen,Ian K. Campbell,Eugene Maraskovsky,Hal Braley,Gayle M. Davey,Patricia L Mottram,Nicholas C. van de Velde,Kent Jensen,Andrew M. Lew,Mark D. Wright,William R. Heath,Ken Shortman,Mireille H. Lahoud +21 more
TL;DR: Targeting Ags to DCs with antibodies to Clec9A is a promising strategy to enhance the efficiency of vaccines, even in the absence of adjuvants.
Journal ArticleDOI
Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype
Mireille H. Lahoud,Fatma Ahmet,Susie Kitsoulis,Soo San Wan,David Vremec,Chin-Nien Lee,Belinda Phipson,Wei Shi,Wei Shi,Gordon K. Smyth,Andrew M. Lew,Yu Kato,Scott N. Mueller,Gayle M. Davey,William R. Heath,Ken Shortman,Ken Shortman,Irina Caminschi,Irina Caminschi +18 more
TL;DR: Potent humoral immunity was a result of the highly specific expression of Clec9A on DCs, which allowed longer residence of targeting Abs in the bloodstream, prolonged DC Ag presentation, and extended CD4 T cell proliferation, all of which drove highly efficient development of follicular helper T cells.
Journal ArticleDOI
DEC-205 is a cell surface receptor for CpG oligonucleotides
Mireille H. Lahoud,Fatma Ahmet,Fatma Ahmet,Jian-Guo Zhang,Simone Meuter,Simone Meuter,Antonia N. Policheni,Susie Kitsoulis,Susie Kitsoulis,Chin-Nien Lee,Meredith O'Keeffe,Lucy C. Sullivan,Andrew G. Brooks,Richard Berry,Jamie Rossjohn,Justine D. Mintern,Justine D. Mintern,Javier Vega-Ramos,Javier Vega-Ramos,Jose A Villadangos,Jose A Villadangos,Nicos A. Nicola,Michel C. Nussenzweig,Katryn J. Stacey,Ken Shortman,Ken Shortman,William R. Heath,Irina Caminschi,Irina Caminschi +28 more
TL;DR: The findings identify an important receptor for class B CpG ODN and reveal a unique function for DEC-205, a multilectin receptor expressed by a variety of cells that is conserved between mouse and man.
Journal ArticleDOI
Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells
Irina Caminschi,Fatma Ahmet,Klaus Heger,Jason Brady,Stephen L. Nutt,David Vremec,Suzanne Pietersz,Mireille H. Lahoud,Louis Schofield,Diana S. Hansen,Meredith O'Keeffe,Mark J. Smyth,Sammy Bedoui,Gayle M. Davey,Jose A Villadangos,William R. Heath,Ken Shortman +16 more
TL;DR: IKDCs resemble NK cells functionally, and neither cell type could be induced to be effective antigen-presenting cells, including those found in DC preparations.
Journal ArticleDOI
The C-Type Lectin Clec12A Present on Mouse and Human Dendritic Cells Can Serve as a Target for Antigen Delivery and Enhancement of Antibody Responses
Mireille H. Lahoud,Anna I Proietto,Fatma Ahmet,Susie Kitsoulis,Liv Eidsmo,Li Wu,Priyanka Sathe,Suzanne Pietersz,Hsuen Wen Chang,Ian D. Walker,Eugene Maraskovsky,Hal Braley,Andrew M. Lew,Mark D. Wright,William R. Heath,Ken Shortman,Irina Caminschi +16 more
TL;DR: The potent Ab responses induced using microgram amounts of anti-Clec12A and minimal amounts of adjuvant demonstrate that this molecule can be used as an Ag-delivery target to enhance Ab responses to vaccines.