C
Chin-Nien Lee
Researcher at Boston Children's Hospital
Publications - 17
Citations - 617
Chin-Nien Lee is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 8, co-authored 15 publications receiving 477 citations. Previous affiliations of Chin-Nien Lee include University of Pennsylvania & Harvard University.
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Journal ArticleDOI
Targeting Antigen to Mouse Dendritic Cells via Clec9A Induces Potent CD4 T Cell Responses Biased toward a Follicular Helper Phenotype
Mireille H. Lahoud,Fatma Ahmet,Susie Kitsoulis,Soo San Wan,David Vremec,Chin-Nien Lee,Belinda Phipson,Wei Shi,Wei Shi,Gordon K. Smyth,Andrew M. Lew,Yu Kato,Scott N. Mueller,Gayle M. Davey,William R. Heath,Ken Shortman,Ken Shortman,Irina Caminschi,Irina Caminschi +18 more
TL;DR: Potent humoral immunity was a result of the highly specific expression of Clec9A on DCs, which allowed longer residence of targeting Abs in the bloodstream, prolonged DC Ag presentation, and extended CD4 T cell proliferation, all of which drove highly efficient development of follicular helper T cells.
Journal ArticleDOI
DEC-205 is a cell surface receptor for CpG oligonucleotides
Mireille H. Lahoud,Fatma Ahmet,Fatma Ahmet,Jian-Guo Zhang,Simone Meuter,Simone Meuter,Antonia N. Policheni,Susie Kitsoulis,Susie Kitsoulis,Chin-Nien Lee,Meredith O'Keeffe,Lucy C. Sullivan,Andrew G. Brooks,Richard Berry,Jamie Rossjohn,Justine D. Mintern,Justine D. Mintern,Javier Vega-Ramos,Javier Vega-Ramos,Jose A Villadangos,Jose A Villadangos,Nicos A. Nicola,Michel C. Nussenzweig,Katryn J. Stacey,Ken Shortman,Ken Shortman,William R. Heath,Irina Caminschi,Irina Caminschi +28 more
TL;DR: The findings identify an important receptor for class B CpG ODN and reveal a unique function for DEC-205, a multilectin receptor expressed by a variety of cells that is conserved between mouse and man.
Journal ArticleDOI
Host non-inflammatory neutrophils mediate the engraftment of bioengineered vascular networks
Ruei-Zeng Lin,Chin-Nien Lee,Chin-Nien Lee,Rafael Moreno-Luna,Rafael Moreno-Luna,Joseph Neumeyer,Breanna L. Piekarski,Pingzhu Zhou,Marsha A. Moses,Monisha Sachdev,William T. Pu,William T. Pu,Sitaram M. Emani,Sitaram M. Emani,Juan M. Melero-Martin,Juan M. Melero-Martin +15 more
TL;DR: The data suggest that the pro-vascularization potential of neutrophils can be harnessed to improve the engraftment of bioengineered tissues.
Journal ArticleDOI
c-Rel Is a Myeloid Checkpoint for Cancer Immunotherapy.
Ting Li,Xinyuan Li,Ali Zamani,Wei Wang,Chin-Nien Lee,Mingyue Li,George Luo,Emily Eiler,Honghong Sun,Sankar Ghosh,Jian Jin,Ramachandran Murali,Qingguo Ruan,Weiyun Shi,Youhai H. Chen +14 more
TL;DR: It is shown that c-Rel, a member of the nuclear factor (NF)-B family, specified the generation of myeloid-derived suppressor cells (MDSCs) by selectively turning on pro-tumoral genes while switching off anti-t tumoral genes through a c- Rel enhanceosome.
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Enhanced antitumor immunity by fusion of CTLA-4 to a self tumor antigen
TL;DR: It is demonstrated that fusing CTLA-4 to a potential tumor antigen represents an effective approach to prime antitumor immunities in vivo and may be applicable to the design of vaccines for a variety of other diseases.