F
Fausto Grignani
Researcher at University of Perugia
Publications - 112
Citations - 11682
Fausto Grignani is an academic researcher from University of Perugia. The author has contributed to research in topics: Leukemia & Acute promyelocytic leukemia. The author has an hindex of 33, co-authored 112 publications receiving 11486 citations. Previous affiliations of Fausto Grignani include French Institute of Health and Medical Research.
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Journal ArticleDOI
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
TL;DR: A flow cytometric method for measuring the percentage of apoptotic nuclei after propidium iodide staining in hypotonic buffer is developed and shown an excellent correlation with the results obtained with both electrophoretic and colorimetric methods.
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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
Giuliana Pelicci,Luisa Lanfrancone,Francesco Grignani,J McGlade,Federica Cavallo,Guido Forni,Ildo Nicoletti,Fausto Grignani,Tony Pawson,Pier Giuseppe Pelicci +9 more
TL;DR: The results suggest that the SHC gene products couple activated growth factor receptors to a signaling pathway that regulates the proliferation of mammalian cells.
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Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.
Fausto Grignani,S De Matteis,Clara Nervi,Lucia Tomassoni,Vania Gelmetti,M Cioce,M Fanelli,M Ruthardt,F F Ferrara,I Zamir,C Seiser,M A Lazar,Saverio Minucci,Pier Giuseppe Pelicci +13 more
TL;DR: It is shown that both PML–RARα and PLZF–Rarα fusion proteins recruit the nuclear co-repressor (N-CoR)–histone deacetylase complex through the RARα CoR box, which determines the differential response of APLs to RA.
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The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells
Francesco Grignani,Pier Francesco Ferrucci,Ugo Testa,Giampaolo Talamo,Marta Fagioli,Myriam Alcalay,Amedea Mencarelli,Fausto Grignani,Cesare Peschle,Cesare Peschle,Ildo Nicoletti,Pier Giuseppe Pelicci +11 more
TL;DR: Expressing the PML-RAR alpha protein in U937 myeloid precursor cells showed that they lost the capacity to differentiate under the action of different stimuli, acquired enhanced sensitivity to retinoic acid, and exhibited a higher growth rate consequent to diminished apoptotic cell death.
Journal Article
High-Efficiency Gene Transfer and Selection of Human Hematopoietic Progenitor Cells with a Hybrid EBV/Retroviral Vector Expressing the Green Fluorescence Protein
Francesco Grignani,Todd Kinsella,Amedea Mencarelli,Mauro Valtieri,Daniela Riganelli,Fausto Grignani,Luisa Lanfrancone,Cesare Peschle,Garry P. Nolan,Pier Giuseppe Pelicci +9 more
TL;DR: The high viral titer and the easy obtainment of homogeneously infected cell populations without drug selection procedures make PINCO an ideal vector for gene transfer of human primary hemopoietic cells.