Journal ArticleDOI
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
Giuliana Pelicci,Luisa Lanfrancone,Francesco Grignani,J McGlade,Federica Cavallo,Guido Forni,Ildo Nicoletti,Fausto Grignani,Tony Pawson,Pier Giuseppe Pelicci +9 more
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TLDR
The results suggest that the SHC gene products couple activated growth factor receptors to a signaling pathway that regulates the proliferation of mammalian cells.About:
This article is published in Cell.The article was published on 1992-07-10. It has received 1355 citations till now. The article focuses on the topics: Shc Signaling Adaptor Proteins & SHC1.read more
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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Jesper V. Olsen,Blagoy Blagoev,Florian Gnad,Boris Macek,Boris Macek,Chanchal Kumar,Peter Mortensen,Matthias Mann +7 more
TL;DR: A general mass spectrometric technology is developed and applied for identification and quantitation of phosphorylation sites as a function of stimulus, time, and subcellular location to provide a missing link in a global, integrative view of cellular regulation.
Journal ArticleDOI
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
TL;DR: This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival, ROS homeostasis and antioxidant gene regulation, mitochondrial oxidative stress, apoptosis, and aging.
Journal ArticleDOI
Role of integrins in cell invasion and migration
John Hood,David A. Cheresh +1 more
TL;DR: As cancer cells undergo metastasis — invasion and migration of a new tissue — they penetrate and attach to the target tissue's basal matrix, which allows the cancer cell to pull itself forward into the tissue.
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The p66shc adaptor protein controls oxidative stress response and life span in mammals
Enrica Migliaccio,Marco Giorgio,Simonetta Mele,Giuliana Pelicci,Paolo Reboldi,Pier Paolo Pandolfi,Luisa Lanfrancone,Pier Giuseppe Pelicci,Pier Giuseppe Pelicci +8 more
TL;DR: It is proposed that p66shc is part of a signal transduction pathway that regulates stress apoptotic responses and life span in mammals.
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ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
TL;DR: Analysis of ErbB receptor interplay induced by the epidermal growth factor (EGF)‐related peptides provides the first biochemical evidence that a given Erb B receptor has distinct signaling properties depending on its dimerization.
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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase.
D B Smith,Kevin S. Johnson +1 more
TL;DR: Plasmid expression vectors have been constructed that direct the synthesis of foreign polypeptides in Escherichia coli as fusions with the C terminus of Sj26, a 26-kDa glutathione S-transferase (GST; EC 2.5.1.18) encoded by the parasitic helminth Schistosoma japonicum.
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Signal transduction by receptors with tyrosine kinase activity
Axel Ullrich,Joseph Schlessinger +1 more
TL;DR: Cet article synthese montre comment des recepteurs membranaires a activite tyrosine kinase peuvent etre impliques dans la transduction and notamment jouent le role de signal de the transduction.
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The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
TL;DR: Phylogenetic mapping of the conserved protein kinase catalytic domains can serve as a useful first step in the functional characterization of these newly identified family members.
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The scanning model for translation: an update.
TL;DR: The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation.