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Felix Gnerlich
Researcher at Ludwig Maximilian University of Munich
Publications - 9
Citations - 1289
Felix Gnerlich is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: DNA demethylation & Phosphoramidite. The author has an hindex of 6, co-authored 9 publications receiving 1163 citations.
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Journal ArticleDOI
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Cornelia G. Spruijt,Felix Gnerlich,Arne H. Smits,Toni Pfaffeneder,Pascal W.T.C. Jansen,Christina Bauer,Martin Münzel,Mirko Wagner,Markus Müller,Fariha Khan,Fariha Khan,H. Christian Eberl,Anneloes Mensinga,Arie B. Brinkman,Konstantin Lephikov,Udo Müller,Jörn Walter,Rolf Boelens,Hugo van Ingen,Heinrich Leonhardt,Thomas Carell,Michiel Vermeulen +21 more
TL;DR: Oxidized derivatives of mC recruit distinct transcription regulators as well as a large number of DNA repair proteins in mouse ES cells, implicating the DNA damage response as a major player in active DNA demethylation.
Journal ArticleDOI
Active DNA demethylation at enhancers during the vertebrate phylotypic period
Ozren Bogdanovic,Ozren Bogdanovic,Ozren Bogdanovic,Arne H. Smits,Elisa de la Calle Mustienes,Juan J. Tena,Ethan Ford,Ethan Ford,Ruth M. Williams,Upeka Senanayake,Matthew D. Schultz,Saartje Hontelez,Ila van Kruijsbergen,Teresa Rayon,Felix Gnerlich,Thomas Carell,Gert Jan C. Veenstra,Miguel Manzanares,Tatjana Sauka-Spengler,Joseph R. Ecker,Michiel Vermeulen,José Luis Gómez-Skarmeta,Ryan Lister,Ryan Lister +23 more
TL;DR: This study reports widespread DNA demethylation of enhancers during the phylotypic period in zebrafish, Xenopus tropicalis and mouse and suggests an ancient developmental role for Tet dioxygenases.
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Improved Synthesis and Mutagenicity of Oligonucleotides Containing 5‐Hydroxymethylcytosine, 5‐Formylcytosine and 5‐Carboxylcytosine
Martin Münzel,Ulrike Lischke,Dimitrios Stathis,Toni Pfaffeneder,Felix Gnerlich,Christian A. Deiml,Sandra C. Koch,Konstantin Karaghiosoff,Thomas Carell +8 more
TL;DR: Efficient syntheses of phosphoramidites are shown which enable the synthesis of DNA strands containing these cytosine modifications based on Pd(0)-catalyzed functionalization of 5-iododeoxycytidine.
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Cell-penetrating and neurotargeting dendritic siRNA nanostructures.
Korbinian Brunner,Johannes Harder,Tobias Halbach,Julian Willibald,Fabio Spada,Felix Gnerlich,Konstantin M. J. Sparrer,Andreas Beil,Leonhard Möckl,Christoph Bräuchle,Karl-Klaus Conzelmann,Thomas Carell +11 more
TL;DR: The development of dendritic siRNA nanostructures that are able to penetrate even difficult to transfect cells such as neurons with the help of a special receptor ligand open up new avenues toward finding novel molecules able to cure this deadly disease.
Journal ArticleDOI
Synthesis of a DNA promoter segment containing all four epigenetic nucleosides: 5-methyl-, 5-hydroxymethyl-, 5-formyl-, and 5-carboxy-2'-deoxycytidine.
Arne S. Schröder,Jessica Steinbacher,Barbara Steigenberger,Felix Gnerlich,Stefan Schiesser,Toni Pfaffeneder,Thomas Carell +6 more
TL;DR: A 5-formyl-2'-deoxycytidine phosphoramidite building block that enables the synthesis of fdC-containing DNA with excellent purity and yield has been developed and it was possible to prepare a segment of the OCT-4 promoter that contains all four epigenetic bases.