F
Feng He
Researcher at University of California, San Diego
Publications - 76
Citations - 5104
Feng He is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 27, co-authored 62 publications receiving 3497 citations. Previous affiliations of Feng He include University of Oklahoma Health Sciences Center & Lanzhou University.
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Journal ArticleDOI
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
Zhenyu Zhong,Atsushi Umemura,Atsushi Umemura,Elsa Sanchez-Lopez,Shuang Liang,Shabnam Shalapour,Jerry Wong,Feng He,Daniela Boassa,Guy Perkins,Syed Raza Ali,Matthew D. McGeough,Mark H. Ellisman,Ekihiro Seki,Ekihiro Seki,Åsa B. Gustafsson,Hal M. Hoffman,Maria T. Diaz-Meco,Jorge Moscat,Michael Karin +19 more
TL;DR: The "NF-κB-p62-mitophagy" pathway is a macrophage-intrinsic regulatory loop through which NF-κBs restrains its own inflammation-promoting activity and orchestrates a self-limiting host response that maintains homeostasis and favors tissue repair.
Journal ArticleDOI
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation
Zhenyu Zhong,Shuang Liang,Elsa Sanchez-Lopez,Feng He,Shabnam Shalapour,Xue Jia Lin,Xue Jia Lin,Jerry Wong,Siyuan Ding,Siyuan Ding,Ekihiro Seki,Bernd Schnabl,Andrea L. Hevener,Harry B. Greenberg,Harry B. Greenberg,Tatiana Kisseleva,Michael Karin +16 more
TL;DR: It is shown that the synthesis of mitochondrial DNA (mtDNA), induced after the engagement of Toll-like receptors, is crucial for NLRP3 signalling, and the dependence on CMPK2 catalytic activity provides opportunities for more effective control ofNLRP3 inflammasome-associated diseases.
Journal ArticleDOI
NRF2, a Transcription Factor for Stress Response and Beyond.
Feng He,Xiaoli Ru,Tao Wen +2 more
TL;DR: The complex regulatory network of NRF2 activity and its roles in metabolic reprogramming, unfolded protein response, proteostasis, autophagy, mitochondrial biogenesis, inflammation, and immunity are summarized.
Journal ArticleDOI
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells
Atsushi Umemura,Feng He,Koji Taniguchi,Hayato Nakagawa,Shinichiro Yamachika,Joan Font-Burgada,Zhenyu Zhong,Shankar Subramaniam,Sindhu Raghunandan,Angeles Duran,Juan F. Linares,Miguel Reina-Campos,Shiori Umemura,Mark A. Valasek,Ekihiro Seki,Kanji Yamaguchi,Kazuhiko Koike,Yoshito Itoh,Maria T. Diaz-Meco,Jorge Moscat,Michael Karin +20 more
TL;DR: It is shown that p62 is necessary and sufficient for HCC induction in mice and that its high expression in non-tumor human liver predicts rapid HCC recurrence after curative ablation.
Journal ArticleDOI
Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study.
Sonia Ancoli-Israel,Barton W. Palmer,Jana R. Cooke,Jody Corey-Bloom,Lavinia Fiorentino,Loki Natarajan,Lianqi Liu,Liat Ayalon,Feng He,Jose S. Loredo +9 more
TL;DR: Whether treatment of obstructive sleep apnea with continuous positive airway pressure with CPAP in patients with Alzheimer's disease results in better cognitive function is examined.