F
Florence Demenais
Researcher at French Institute of Health and Medical Research
Publications - 228
Citations - 14269
Florence Demenais is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 58, co-authored 225 publications receiving 13069 citations. Previous affiliations of Florence Demenais include Institut Gustave Roussy & Foundation Center.
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Familial susceptibility to breast cancer: A complex inheritance
TL;DR: The main results of segregation analysis show that the existence of a single major gene is not sufficient to explain the distributions of the disease observed in the families concerned and suggest that the genetic inheritance involved is heterogeneous and complex.
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Further analysis of familial transmission of congenital glaucoma.
TL;DR: A re-analysis of familial transmission of congenital glaucoma is performed here using the unified model and considering, respectively, joint and conditional likelihoods.
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The transmission probability model is useful to prevent false inference.
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Consanguinity in Multifactorial Inheritance
TL;DR: The increase of parental consanguinity in multifactorial inheritance is evaluated by calculating the expected incidence of affected children whose parents are first cousins, using several values, namely for condition frequency and heritability of liability.
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How can maximum likelihood methods reveal candidate gene effects on a quantitative trait
TL;DR: The combined segregation and linkage analysis clearly shows that a C5 linked gene is involved in Q1 variability, and the value of simultaneous estimation of linkage and segregation parameters is demonstrated.