F
Florence Demenais
Researcher at French Institute of Health and Medical Research
Publications - 228
Citations - 14269
Florence Demenais is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 58, co-authored 225 publications receiving 13069 citations. Previous affiliations of Florence Demenais include Institut Gustave Roussy & Foundation Center.
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Journal Article
EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy)-- descriptive characteristics.
Francine Kauffmann,M H Dizier,I. Annesi-Maesano,Jean Bousquet,Denis Charpin,Florence Demenais,D. Ecochard,Josué Feingold,Frédéric Gormand,Alain Grimfeld,Mark Lathrop,Régis Matran,Françoise Neukirch,Evelyne Paty,Isabelle Pin,Christophe Pison,Pierre Scheinmann,Daniel Vervloet,Alain Lockhart +18 more
TL;DR: Prevalences of asthma, skin prick test response, high IgE and bronchial hyperresponsiveness were for parents, siblings, and offspring of cases intermediate between cases and spouses or controls, both in adults and children, confirming the familial resemblance for asthma and related traits.
Journal Article
Robustness and power of the unified model in the analysis of quantitative measurements.
TL;DR: It was shown that use of a transformation to remove skewness induced by a major gene leads to a decrease of power of approximately 55%.
Journal ArticleDOI
A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2–q22 linked to type 2 diabetes
Florence Demenais,Timo Kanninen,Cecilia M. Lindgren,Steven Wiltshire,Stéphane Gaget,Candice Dandrieux,Peter Almgren,Marketa Sjögren,Andrew T. Hattersley,Christian Dina,Tiinamaija Tuomi,Mark I. McCarthy,Mark I. McCarthy,Philippe Froguel,Leif Groop +14 more
TL;DR: A meta-analysis of four scans conducted in European samples led to identification of a novel region on chromosome 17 linked to type 2 diabetes; this region has not been highlighted in any published scan to date but on the basis of these data justifies further exploration.
Journal ArticleDOI
Genome-wide association study of body mass index in 23,000 individuals with and without asthma
Erik Melén,Erik Melén,Erik Melén,Raquel Granell,Manolis Kogevinas,David P. Strachan,J. R. Gonzalez,M. Wjst,Deborah Jarvis,Markus J. Ege,Charlotte Braun-Fahrländer,Charlotte Braun-Fahrländer,Jon Genuneit,Elisabeth Horak,Emmanuelle Bouzigon,Emmanuelle Bouzigon,Emmanuelle Bouzigon,Florence Demenais,Florence Demenais,Florence Demenais,Francine Kauffmann,Valérie Siroux,Sven Michel,A. von Berg,Andrea Heinzmann,Michael Kabesch,Nicole Probst-Hensch,Nicole Probst-Hensch,Ivan Curjuric,Ivan Curjuric,Medea Imboden,Medea Imboden,T. Rochat,John Henderson,Jonathan A C Sterne,Wendy L. McArdle,Jennie Hui,Alan James,Alan James,A. William Musk,A. William Musk,Lyle J. Palmer,Lyle J. Palmer,Allan B. Becker,Anita L. Kozyrskyj,Anita L. Kozyrskyj,M. Chan-Young,Julie E. Park,A. Leung,Denise Daley,Maxim B. Freidin,Ivan Deev,L. M. Ogorodova,V. P. Puzyrev,V. P. Puzyrev,Juan C. Celedón,J. M. Brehm,Michelle M. Cloutier,Glorisa Canino,Edna Acosta-Pérez,Manuel E. Soto-Quiros,Lydiana Avila,Anna Bergström,Jessica Magnusson,Cilla Söderhäll,Inger Kull,Salome Scholtens,H. Marike Boezen,Gerard H. Koppelman,A. H. Wijga,Ingo Marenholz,Jorge Esparza-Gordillo,Steffen Lau,Young-Ae Lee,M. Standl,Carla M. T. Tiesler,C Flexeder,Joachim Heinrich,Rachel A. Myers,Carole Ober,Dan L. Nicolae,Martin Farrall,Ashok Kumar,Ashok Kumar,Ashok Kumar,Miriam F. Moffatt,W. Cookson,Jessica Lasky-Su +87 more
TL;DR: Shared genetic factors between asthma and obesity have been proposed to partly explain epidemiological findings of co‐morbidity between these conditions.
Journal ArticleDOI
Linkage Analysis and Molecular Scanning of Glucokinase Gene in NIDDM Families
Habib Zouali,Marine Vaxillaire,Suzanne Lesage,F. Sun,Gilberto Velho,Nathalie Vionnet,Ken C. Chiu,Philippe Passa,Alan Permutt,Florence Demenais,Daniel Cohen,Jacques S. Beckmann,Philippe Froguel +12 more
TL;DR: No evidence was obtained to incriminate glucokinase as a major gene for late age of onset NIDDM, and pregnancy reveals diabetes in women carrying a glucokin enzyme defect.