F
Florence Demenais
Researcher at French Institute of Health and Medical Research
Publications - 228
Citations - 14269
Florence Demenais is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 58, co-authored 225 publications receiving 13069 citations. Previous affiliations of Florence Demenais include Institut Gustave Roussy & Foundation Center.
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Journal ArticleDOI
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma.
Jiyeon Choi,Tongwu Zhang,Andrew Vu,Julien Ablain,Matthew M. Makowski,Leandro M. Colli,Mai Xu,Rebecca C Hennessey,Jinhu Yin,Harriet Rothschild,Cathrin Gräwe,Michael A. Kovacs,Karen M. Funderburk,Myriam Brossard,John C. Taylor,Bogdan Pasaniuc,Raj Chari,Stephen J. Chanock,Clive J. Hoggart,Florence Demenais,Jennifer H. Barrett,Matthew Law,Mark M. Iles,Kai Yu,Michiel Vermeulen,Leonard I. Zon,Kevin M. Brown +26 more
TL;DR: It is demonstrated that expression of one such gene, MX2, leads to the promotion of melanoma in a zebrafish model, and the integrative approach streamlines GWAS follow-up studies and highlights a pleiotropic function of MX2 in melanoma susceptibility.
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Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Matthew Law,D. Timothy Bishop,Jeffrey E. Lee,Myriam Brossard,Nicholas G. Martin,Eric K. Moses,Fengju Song,Jennifer H. Barrett,Rajesh Kumar,Douglas F. Easton,Paul D.P. Pharoah,Anthony J. Swerdlow,Katerina P. Kypreou,John C. Taylor,Mark Harland,Juliette Randerson-Moor,Lars A. Akslen,Per Arne Andresen,Marie-Françoise Avril,Esther Azizi,Giovanna Bianchi Scarrà,Kevin M. Brown,Tadeusz Dębniak,David L. Duffy,David E. Elder,Shenying Fang,Eitan Friedman,Pilar Galan,Paola Ghiorzo,Elizabeth M. Gillanders,Alisa M. Goldstein,Nelleke A. Gruis,Johan Hansson,Per Helsing,Marko Hočevar,Veronica Höiom,Christian Ingvar,Peter A. Kanetsky,Wei V. Chen,Maria Teresa Landi,Julie Lang,G. Mark Lathrop,Jan Lubinski,Rona M. MacKie,Graham J. Mann,Anders Molven,Grant W. Montgomery,Srdjan Novaković,Håkan Olsson,Susana Puig,Joan Anton Puig-Butille,Abrar A. Qureshi,Graham L. Radford-Smith,Nienke van der Stoep,Remco van Doorn,David C. Whiteman,Jamie E Craig,Dirk Schadendorf,Lisa A. Simms,Kathryn P. Burdon,Dale R. Nyholt,Karen A. Pooley,Nick Orr,Alexander J. Stratigos,Anne E. Cust,Sarah V. Ward,Nicholas K. Hayward,Jiali Han,Hans Joachim Schulze,Alison M. Dunning,Julia A. Newton Bishop,Florence Demenais,Christopher I. Amos,Stuart MacGregor,Mark M. Iles +74 more
TL;DR: An international 2-stage meta-analysis of CMM genome-wide association studies (GWAS) combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls, finding five loci not previously associated with CMM risk reached genome- wide significance.
Journal ArticleDOI
Indication for Linkage of the Human OB Gene Region With Extreme Obesity
Karine Clément,Chad Garner,Jörg Hager,Anne Philippi,Carrie LeDuc,Alisoun H. Carey,Timothy J. R. Harris,Corinne Jury,Lon R. Cardon,Arnaud Basdevant,Florence Demenais,Bernard Guy-Grand,Michael North,Philippe Froguel +13 more
TL;DR: The OB gene is a candidate for genetic predisposition to extreme obesity in a subset of these families and was established by radiation hybrid mapping and eight microsatellite markers spanning the OB gene region (7q3l.3) were genotyped in 101 obese French families.
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A Susceptibility Locus for Early-Onset Non-Insulin Dependent (Type 2) Diabetes Mellitus Maps to Chromosome 20q, Proximal to the Phosphoenolpyruvate Carboxykinase Gene
Habib Zouali,El Habib Hani,Anne Philippi,Nathalie Vionnet,Jacques S. Beckmann,Florence Demenais,Philippe Froguel +6 more
TL;DR: The study suggests the location of a susceptibility locus for early onset NIDDM in the PCK1 gene region, and further investigation in larger data sets is required to confirm these results and assess the role of other regions on chromosome 20q in human NID DM.
Journal ArticleDOI
Dissecting the loci controlling fetal haemoglobin production on chromosomes 11p and 6q by the regressive approach.
Jamie E Craig,Jacques Rochette,Chris Fisher,David J. Weatherall,S Marc,G. M. Lathrop,G. M. Lathrop,Florence Demenais,Swee Lay Thein +8 more
TL;DR: It is demonstrated that in addition to the two factors (β thalassaemia and Xmn l-Gγ site) on chromosome 11 p, there is a third major genetic determinant for fetal Hb production localized on chromosome 6q.