F
Florian Zink
Researcher at deCODE genetics
Publications - 23
Citations - 3327
Florian Zink is an academic researcher from deCODE genetics. The author has contributed to research in topics: Population & Biology. The author has an hindex of 15, co-authored 19 publications receiving 2707 citations. Previous affiliations of Florian Zink include Amgen.
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Journal ArticleDOI
Genetics of gene expression and its effect on disease
Valur Emilsson,Gudmar Thorleifsson,Bin Zhang,Amy Leonardson,Florian Zink,Jun Zhu,Sonia Carlson,Agnar Helgason,G. Bragi Walters,Steinunn Gunnarsdottir,Magali Mouy,Valgerdur Steinthorsdottir,Gudrun H. Eiriksdottir,Gyda Bjornsdottir,Inga Reynisdottir,Daniel F. Gudbjartsson,Anna Helgadottir,Aslaug Jonasdottir,Adalbjorg Jonasdottir,Unnur Styrkarsdottir,Solveig Gretarsdottir,Kristinn P. Magnusson,Hreinn Stefansson,Ragnheidur Fossdal,Kristleifur Kristjansson,Hjörtur Gislason,Tryggvi Stefansson,Björn Geir Leifsson,Unnur Thorsteinsdottir,John Lamb,Jeffrey R. Gulcher,Marc L. Reitman,Augustine Kong,Eric E. Schadt,Kari Stefansson +34 more
TL;DR: An extensive transcriptional network constructed from the human adipose data that exhibits significant overlap with similar network modules constructed from mouse adiposeData was identified that is enriched for genes involved in the inflammatory and immune response and has been found to be causally associated to obesity-related traits.
Journal ArticleDOI
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly.
Florian Zink,Simon N. Stacey,Gudmundur L. Norddahl,Michael L. Frigge,Olafur T. Magnusson,Ingileif Jonsdottir,Ingileif Jonsdottir,Thorgeir E. Thorgeirsson,Asgeir Sigurdsson,Sigurjon A. Gudjonsson,Julius Gudmundsson,Jon G. Jonasson,Laufey Tryggvadottir,Thorvaldur Jonsson,Agnar Helgason,Arnaldur Gylfason,Patrick Sulem,Thorunn Rafnar,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Gisli Masson,Augustine Kong,Kari Stefansson,Kari Stefansson +25 more
TL;DR: It is found that CH is very common in the elderly, trending toward inevitability, and somatic mutations in TET2, DNMT3A, ASXL1, and PPM1D are associated with CH at high significance, however, known CD mutations were evident in only a fraction of CH cases.
Journal ArticleDOI
Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial.
Hakon Hakonarson,Sverrir Thorvaldsson,Anna Helgadottir,Daniel F. Gudbjartsson,Florian Zink,Margret B. Andresdottir,Andrei Manolescu,David O. Arnar,Karl Andersen,Axel Sigurdsson,Gestur Thorgeirsson,Asgeir Jonsson,Uggi Agnarsson,Halldora Bjornsdottir,Gizur Gottskalksson,Atli Einarsson,Hrefna Gudmundsdottir,Asdis E. Adalsteinsdottir,Kolbeinn Gudmundsson,Kristleifur Kristjansson,Thordur Hardarson,Arni Kristinsson,Eric J. Topol,Jeffrey R. Gulcher,Augustine Kong,Mark E. Gurney,Gudmundur Thorgeirsson,Kari Stefansson +27 more
TL;DR: In patients with specific at-risk variants of 2 genes in the leukotriene pathway, DG-031 led to significant and dose-dependent suppression of biomarkers that are associated with increased risk of MI events.
Journal ArticleDOI
Characterizing mutagenic effects of recombination through a sequence-level genetic map.
Bjarni V. Halldorsson,Bjarni V. Halldorsson,Gunnar K. Pálsson,Olafur A. Stefansson,Hakon Jonsson,Marteinn T. Hardarson,Hannes P. Eggertsson,Hannes P. Eggertsson,Bjarni Gunnarsson,Asmundur Oddsson,Gisli H. Halldorsson,Florian Zink,Sigurjon A. Gudjonsson,Michael L. Frigge,Gudmar Thorleifsson,Asgeir Sigurdsson,Simon N. Stacey,Patrick Sulem,Gisli Masson,Agnar Helgason,Agnar Helgason,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Kari Stefansson,Kari Stefansson +26 more
TL;DR: The detection of recombination and de novo mutations (DNMs) requires genetic data on a proband and its parents, and a fine resolution of these events is possible only with whole-genome sequence data, allowing us to identify crossovers and DNMs in families at a high resolution.
Journal ArticleDOI
Graphtyper enables population-scale genotyping using pangenome graphs
Hannes P. Eggertsson,Hannes P. Eggertsson,Hakon Jonsson,Snaedis Kristmundsdottir,Snaedis Kristmundsdottir,Eirikur Hjartarson,Birte Kehr,Gisli Masson,Florian Zink,Kristjan E. Hjorleifsson,Aslaug Jonasdottir,Adalbjorg Jonasdottir,Ingileif Jonsdottir,Ingileif Jonsdottir,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Páll Melsted,Páll Melsted,Kari Stefansson,Kari Stefansson,Bjarni V. Halldorsson,Bjarni V. Halldorsson +21 more
TL;DR: Graphtyper as discussed by the authors realigns short-read sequence data to a pangenome, a variation-aware graph structure that encodes sequence variation within a population by representing possible haplotypes as graph paths.