K
Karl Andersen
Researcher at University of Iceland
Publications - 94
Citations - 8378
Karl Andersen is an academic researcher from University of Iceland. The author has contributed to research in topics: Coronary artery disease & Myocardial infarction. The author has an hindex of 29, co-authored 88 publications receiving 7680 citations. Previous affiliations of Karl Andersen include RMIT University & Sahlgrenska University Hospital.
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Journal ArticleDOI
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Heribert Schunkert,Inke R. König,Sekar Kathiresan,Muredach P. Reilly,Themistocles L. Assimes,Hilma Holm,Michael Preuss,Alexandre F.R. Stewart,Maja Barbalić,Christian Gieger,Devin Absher,Zouhair Aherrahrou,Hooman Allayee,David Altshuler,Sonia S. Anand,Karl Andersen,Jeffrey L. Anderson,Diego Ardissino,Stephen G. Ball,Anthony J. Balmforth,Timothy A. Barnes,Diane M. Becker,Lewis C. Becker,Klaus Berger,Joshua C. Bis,S. Matthijs Boekholdt,Eric Boerwinkle,Peter S. Braund,Morris J. Brown,Mary Susan Burnett,Ian Buysschaert,John F. Carlquist,Li Chen,Sven Cichon,Veryan Codd,Robert W. Davies,George Dedoussis,Abbas Dehghan,Serkalem Demissie,Joseph M. Devaney,Patrick Diemert,Ron Do,Angela Doering,Sandra Eifert,Nour Eddine El Mokhtari,Stephen G. Ellis,Roberto Elosua,James C. Engert,Stephen E. Epstein,Ulf de Faire,Marcus Fischer,Aaron R. Folsom,Jennifer Freyer,Bruna Gigante,Domenico Girelli,Solveig Gretarsdottir,Vilmundur Gudnason,Jeffrey R. Gulcher,Eran Halperin,Naomi Hammond,Stanley L. Hazen,Albert Hofman,Benjamin D. Horne,Thomas Illig,Carlos Iribarren,Gregory T. Jones,J. Wouter Jukema,Michael A. Kaiser,Lee M. Kaplan,John J.P. Kastelein,Kay-Tee Khaw,Joshua W. Knowles,G. Kolovou,Augustine Kong,Reijo Laaksonen,Diether Lambrechts,Karin Leander,Guillaume Lettre,Mingyao Li,Wolfgang Lieb,Christina Loley,Andrew J. Lotery,Pier Mannuccio Mannucci,Seraya Maouche,Nicola Martinelli,Pascal P. McKeown,Christa Meisinger,Thomas Meitinger,Olle Melander,Pier Angelica Merlini,Vincent Mooser,Thomas M. Morgan,Thomas W. Mühleisen,Joseph B. Muhlestein,Thomas Münzel,Kiran Musunuru,Janja Nahrstaedt,Christopher P. Nelson,Markus M. Nöthen,Oliviero Olivieri,Riyaz S. Patel,Christopher Patterson,Annette Peters,Flora Peyvandi,Liming Qu,Arshed A. Quyyumi,Daniel J. Rader,Loukianos S. Rallidis,Catherine M. Rice,Frits R. Rosendaal,Diana Rubin,Veikko Salomaa,M. Lourdes Sampietro,M. S. Sandhu,Eric E. Schadt,Arne Scḧsignfer,Arne Schillert,Stefan Schreiber,Jürgen Schrezenmeir,Stephen M. Schwartz,David S. Siscovick,Mohan U. Sivananthan,Suthesh Sivapalaratnam,Albert V. Smith,Tamara B. Smith,Jaapjan D. Snoep,Nicole Soranzo,John A. Spertus,Klaus Stark,Kathy Stirrups,Monika Stoll,W.H. Wilson Tang,Stephanie Tennstedt,Gudmundur Thorgeirsson,Gudmar Thorleifsson,Maciej Tomaszewski,André G. Uitterlinden,Andre M. van Rij,Benjamin F. Voight,Nicholas J. Wareham,George A. Wells,H.-Erich Wichmann,Philipp S. Wild,Christina Willenborg,Jaqueline C M Witteman,Benjamin J. Wright,Shu Ye,Tanja Zeller,Andreas Ziegler,François Cambien,Alison H. Goodall,L. Adrienne Cupples,Thomas Quertermous,Winfried Mäsignrz,Christian Hengstenberg,Stefan Blankenberg,Willem H. Ouwehand,Alistair S. Hall,Panos Deloukas,John R. Thompson,Kari Stefansson,Robert Roberts,Unnur Thorsteinsdottir,Christopher J. O'Donnell,Ruth McPherson,Jeanette Erdmann,Nilesh J. Samani +166 more
TL;DR: This paper performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals.
Journal ArticleDOI
A Common Variant on Chromosome 9p21 Affects the Risk of Myocardial Infarction
Anna Helgadottir,Gudmar Thorleifsson,Andrei Manolescu,Solveig Gretarsdottir,Thorarinn Blondal,Aslaug Jonasdottir,Abalbjorg Jonasdottir,Asgeir Sigurdsson,Adam Baker,Arnar Palsson,Gisli Masson,Daniel F. Gudbjartsson,Kristinn P. Magnusson,Karl Andersen,Allan I. Levey,Valgerdur M Backman,Sigurborg Matthiasdottir,Thorbjorg Jonsdottir,Stefan T Palsson,Helga Einarsdottir,Steinunn Gunnarsdottir,Arnaldur Gylfason,Viola Vaccarino,W. Craig Hooper,Muredach P. Reilly,Christopher B. Granger,Harland Austin,Daniel J. Rader,Svati H. Shah,Arshed A. Quyyumi,Jeffrey R. Gulcher,Gudmundur Thorgeirsson,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +34 more
TL;DR: An association between myocardial infarction and a common sequence variant on chromosome 9p21 was associated with the disease with high significance and approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardious disease is 1.64 times as great as that of noncarriers.
Journal ArticleDOI
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
Anna Helgadottir,Gudmar Thorleifsson,Kristinn P. Magnusson,Solveig Gretarsdottir,Valgerdur Steinthorsdottir,Andrei Manolescu,Gregory T. Jones,Gabriel J.E. Rinkel,Jan D. Blankensteijn,Antti Ronkainen,Juha Jääskeläinen,Yoshiki Kyo,Guy M. Lenk,Natzi Sakalihasan,Konstantinos Kostulas,Anders Gottsäter,Andrea Flex,Hreinn Stefansson,Torben Hansen,Gitte Andersen,Shantel Weinsheimer,Knut Borch-Johnsen,Knut Borch-Johnsen,Torben Jørgensen,Svati H. Shah,Arshed A. Quyyumi,Christopher B. Granger,Muredach P. Reilly,Harland Austin,Allan I. Levey,Viola Vaccarino,Ebba Palsdottir,G. Bragi Walters,Thorbjorg Jonsdottir,Steinunn Snorradottir,Dana Magnusdottir,Gudmundur H. Gudmundsson,Robert E. Ferrell,Sigurlaug Sveinbjörnsdóttir,Juha Hernesniemi,Juha Hernesniemi,Mika Niemelä,Raymond Limet,Karl Andersen,Gunnar Sigurdsson,Rafn Benediktsson,Eric L.G. Verhoeven,Joep A.W. Teijink,Diederick E. Grobbee,Daniel J. Rader,David A. Collier,Oluf Pedersen,Roberto Pola,Jan Hillert,Bengt Lindblad,Einar M. Valdimarsson,Hulda B Magnadottir,Cisca Wijmenga,Gerard Tromp,Annette F. Baas,Ynte M. Ruigrok,Andre M. van Rij,Helena Kuivaniemi,Janet T. Powell,Stefan E Matthiasson,Jeffrey R. Gulcher,Gudmundur Thorgeirsson,Augustine Kong,Unnur Thorsteinsdottir,Kari Stefansson +69 more
TL;DR: It is reported that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA) and intracranial aneurYSm, but not with T2D, and the role of this sequence variant is not confined to atherosclerotic diseases.
Journal ArticleDOI
A common variant on chromosome 9p21 affects the risk of myocardial infarction
Anna Helgadottir,Gudmar Thorleifsson,Andrei Manolescu,Solveig Gretarsdottir,Thorarinn Blondal,Aslaug Jonasdottir,Abalbjorg Jonasdottir,Asgeir Sigurdsson,Adam Baker,Arnar Palsson,Gisli Masson,Daniel F. Gudbjartsson,Kristinn P. Magnusson,Karl Andersen,Allan I. Levey,Valgerdur M Backman,Sigurborg Matthiasdottir,Thorbjorg Jonsdottir,Stefan T Palsson,Helga Einarsdottir,Steinunn Gunnarsdottir,Arnaldur Gylfason,Viola Vaccarino,W. Craig Hooper,Muredach P. Reilly,Christopher B. Granger,Harland Austin,Daniel J. Rader,Svati H. Shah,Arshed A. Quyyumi,Jeffrey R. Gulcher,Gudmundur Thorgeirsson,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +34 more
TL;DR: An association between myocardial infarction and a common sequence variant on chromosome 9p21 was associated with the disease with high significance and approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardious disease is 1.64 times as great as that of noncarriers.
Journal ArticleDOI
Angiotensin Receptor Neprilysin Inhibition Compared With Enalapril on the Risk of Clinical Progression in Surviving Patients With Heart Failure
Milton Packer,John J.V. McMurray,Akshay S. Desai,Jianjian Gong,Martin Lefkowitz,Adel R. Rizkala,Jean L. Rouleau,Victor Shi,Scott D. Solomon,Karl Swedberg,Michael R. Zile,Karl Andersen,Juan Luis Arango,J. Malcolm O. Arnold,Jan Belohlavek,Michael Böhm,Sergey Boytsov,Lesley J. Burgess,Walter Cabrera,Carlos Calvo,Chen Huan Chen,Andrej Dukát,Yan Carlos Duarte,Andrejs Erglis,Michael Fu,Efrain Gomez,Angel Gonzàlez-Medina,Albert A. Hagège,Jun Huang,Tzventana Katova,Songsak Kiatchoosakun,Kee-Sik Kim,Ömer Kozan,Edmundo Alfredo Bayram Llamas,Felipe Martinez,Béla Merkely,Ivan Mendoza,Arend Mosterd,Marta Negrusz-Kawecka,Keijo Peuhkurinen,Felix José Alvarez Ramires,Jens Refsgaard,Arvo Rosenthal,Michele Senni,Antonio S. Sibulo,José Silva-Cardoso,Iain B. Squire,Randall C. Starling,John R. Teerlink,Johan Vanhaecke,Dragos Vinereanu,Raymond Ching-Chiew Wong +51 more
TL;DR: Angiotensin-neprilysin inhibition prevents the clinical progression of surviving patients with heart failure more effectively than angiotens in-converting enzyme inhibition.