F
Francesc Castro-Giner
Researcher at Swiss Institute of Bioinformatics
Publications - 52
Citations - 4464
Francesc Castro-Giner is an academic researcher from Swiss Institute of Bioinformatics. The author has contributed to research in topics: Circulating tumor cell & Metastasis. The author has an hindex of 28, co-authored 49 publications receiving 3036 citations. Previous affiliations of Francesc Castro-Giner include Wellcome Trust Centre for Human Genetics & Pompeu Fabra University.
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Journal ArticleDOI
Neutrophils escort circulating tumour cells to enable cell cycle progression
Barbara Maria Szczerba,Francesc Castro-Giner,Francesc Castro-Giner,Marcus Vetter,Ilona Krol,Sofia Gkountela,Julia Landin,Manuel C. Scheidmann,Cinzia Donato,Ramona Scherrer,Jochen Singer,Jochen Singer,Christian Beisel,Christian Kurzeder,Viola Heinzelmann-Schwarz,Christoph Rochlitz,Walter P. Weber,Niko Beerenwinkel,Niko Beerenwinkel,Nicola Aceto +19 more
TL;DR: The authors show that circulating tumour cells can be found in association with neutrophils, an interaction which supports their proliferation and their ability to seed metastasis, providing a rationale for targeting this interaction in treatment of breast cancer.
Journal ArticleDOI
Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding.
Sofia Gkountela,Francesc Castro-Giner,Francesc Castro-Giner,Barbara Maria Szczerba,Marcus Vetter,Julia Landin,Ramona Scherrer,Ilona Krol,Manuel C. Scheidmann,Christian Beisel,Christian U. Stirnimann,Christian Kurzeder,Viola Heinzelmann-Schwarz,Christoph Rochlitz,Walter P. Weber,Nicola Aceto +15 more
TL;DR: The results link CTC clustering to specific changes in DNA methylation that promote stemness and metastasis and point to cluster-targeting compounds to suppress the spread of cancer.
Journal ArticleDOI
Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency
Michal Kovac,Claudia Blattmann,Sebastian Ribi,Jan Smida,Nikola S. Mueller,Florian Engert,Francesc Castro-Giner,Joachim Weischenfeldt,Monika Kovacova,Andreas H. Krieg,Dimosthenis Andreou,Per-Ulf Tunn,Hans Roland Dürr,Hans Rechl,Klaus-Dieter Schaser,Ingo Melcher,Stefan Burdach,Andreas E. Kulozik,Katja Specht,Karl Heinimann,Simone Fulda,Simone Fulda,Stefan S. Bielack,Gernot Jundt,Ian Tomlinson,Jan O. Korbel,Michaela Nathrath,Daniel Baumhoer +27 more
TL;DR: It is implied that multiple oncogenic pathways drive chromosomal instability during osteosarcoma evolution and result in the acquisition of BRCA-like traits, which could be therapeutically exploited.
Journal ArticleDOI
Air pollution, oxidative stress and dietary supplementation: a review
TL;DR: There is substantial evidence that air pollution exposure results in increased oxidative stress and that dietary supplementation may play a modulating role on the acute effect of air pollutants.
Journal ArticleDOI
Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy.
Cristina Balbás-Martínez,Ana Sagrera,Enrique Carrillo-de-Santa-Pau,Julie Earl,Mirari Marquez,Miguel Vazquez,Eleonora Lapi,Francesc Castro-Giner,Sergi Beltran,Mònica Bayés,Alfredo Carrato,Juan C. Cigudosa,Orlando Domínguez,Marta Gut,Jesús Herranz,Nuria Juanpere,Manolis Kogevinas,Xavier Langa,Elena Lopez-Knowles,José A. Lorente,Josep Lloreta,David G. Pisano,Laia Richart,Daniel Rico,Rocío Salgado,Adonina Tardón,Stephen J. Chanock,Simon Heath,Alfonso Valencia,Ana Losada,Ivo Gut,Núria Malats,Francisco X. Real +32 more
TL;DR: It is indicated that STAG2 is a new UBC tumor suppressor acting through mechanisms that are different from its role in preventing aneuploidy, and its loss was associated with improved outcome.