M
Michaela Nathrath
Researcher at Technische Universität München
Publications - 94
Citations - 4595
Michaela Nathrath is an academic researcher from Technische Universität München. The author has contributed to research in topics: Cancer & Osteosarcoma. The author has an hindex of 28, co-authored 78 publications receiving 3466 citations. Previous affiliations of Michaela Nathrath include German Cancer Research Center & Boston Children's Hospital.
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Journal ArticleDOI
The landscape of genomic alterations across childhood cancers
Susanne Gröbner,Barbara C. Worst,Joachim Weischenfeldt,Joachim Weischenfeldt,Ivo Buchhalter,Kortine Kleinheinz,Vasilisa A. Rudneva,Pascal Johann,Gnana Prakash Balasubramanian,Maia Segura-Wang,Sebastian Brabetz,Sebastian Bender,Barbara Hutter,Dominik Sturm,Elke Pfaff,Daniel Hübschmann,Gideon Zipprich,Michael Heinold,Michael Heinold,Jürgen Eils,Christian Lawerenz,Serap Erkek,Sander Lambo,Sebastian M. Waszak,Claudia Blattmann,Arndt Borkhardt,Arndt Borkhardt,Michaela Kuhlen,Michaela Kuhlen,Angelika Eggert,Angelika Eggert,Simone Fulda,Manfred Gessler,Jenny Wegert,Roland Kappler,Roland Kappler,Daniel Baumhoer,Stefan Burdach,Stefan Burdach,Renate Kirschner-Schwabe,Renate Kirschner-Schwabe,Udo Kontny,Andreas E. Kulozik,Andreas E. Kulozik,Dietmar R. Lohmann,Simone Hettmer,Cornelia Eckert,Cornelia Eckert,Stefan S. Bielack,Michaela Nathrath,Michaela Nathrath,Charlotte M. Niemeyer,Charlotte M. Niemeyer,Gunther Richter,Gunther Richter,Johannes H. Schulte,Johannes H. Schulte,Reiner Siebert,Frank Westermann,Jan J. Molenaar,Gilles Vassal,Hendrik Witt,Peter Lichter,Ursula Weber,Roland Eils,Roland Eils,Andrey Korshunov,Olaf Witt,Stefan Pfister,Guido Reifenberger,J Felsberg,Christof von Kalle,Manfred Schmidt,Cynthia Bartholomä,Michael Taylor,David T. W. Jones,Natalie Jäger,Korbel Jo,Adrian M. Stütz,Tobias Rausch,Bernhard Radlwimmer,Marie-Laure Yaspo,Hans Lehrach,Hans-Jörg Warnatz,Pablo Landgraf,Benedikt Brors,Marc Zapatka,Marc Zapatka,Susanne Wagner,Susanne Wagner,Andrea Haake,Julia Richter,Gesine Richter,Gesine Richter,Chris Lawerenz,Jules Kerssemakers,Christina Jaeger-Schmidt,Ingrid Scholz,Anke K. Bergmann,Christoph Borst,Birgit Burkhardt,Alexander Claviez,Martin Dreyling,Martin Dreyling,Sonja Eberth,Hermann Einsele,Norbert Frickhofen,Siegfried Haas,Martin-Leo Hansmann,Dennis Karsch,Michael Kneba,Jasmin Lisfeld,Luisa Mantovani-Löffler,Marius Rohde,German Ott,Christina Stadler,Peter Staib,Stephan Stilgenbauer,Lorenz Trümper,Thorsten Zenz,Dieter Kube,Ralf Küppers,Marc A. Weniger,Michael Hummel,Wolfram Klapper,Ulrike Kostezka,Dido Lenze,Peter Möller,Andreas Rosenwald,Monika Szczepanowski,Ole Ammerpohl,Sietse M. Aukema,Vera Binder,Jessica I. Hoell,Ellen Leich,Cristina López,Inga Nagel,Jordan Pischimariov,Philip Rosenstiel,Markus Schilhabel,Stefan Schreiber,Inga Vater,Rabea Wagener,Stephan H. Bernhart,Hans Binder,Gero Doose,Steve Hoffmann,Lydia Hopp,Helene Kretzmer,Markus Kreuz,David Langenberger,Markus Loeffler,Maciej Rosolowski,Matthias Schlesner,Peter F. Stadler,Stephanie Sungalee,Christian P. Kratz,Cornelis M. van Tilburg,Christof M. Kramm,Gudrun Fleischhack,Gudrun Fleischhack,Uta Dirksen,Stefan Rutkowski,Michael C. Frühwald,Katja von Hoff,Stephan Wolf,Thomas Klingebiel,Thomas Klingebiel,Ewa Koscielniak,Jan Koster,Adam C. Resnick,Jinghui Zhang,Yanling Liu,Xin Zhou,Angela J. Waanders,Danny A. Zwijnenburg,Pichai Raman,Ursula D. Weber,Paul A. Northcott,Kristian W. Pajtler,Marcel Kool,Rosario M. Piro,Jan O. Korbel,David T.W. Jones,Lukas Chavez,Stefan M. Pfister +185 more
TL;DR: The data suggest that 7–8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.
Journal ArticleDOI
Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial
Neyssa Marina,Sigbjørn Smeland,Stefan S. Bielack,Mark L. Bernstein,Gordana Jovic,Mark Krailo,Jane Hook,Jane Hook,Carola A.S. Arndt,Henk van den Berg,Bernadette Brennan,Bénédicte Brichard,Kenneth L.B. Brown,Trude Butterfass-Bahloul,Gabriele Calaminus,Heike E. Daldrup-Link,Mikael Eriksson,Mark C. Gebhardt,Hans Gelderblom,Joachim Gerss,Robert E. Goldsby,Allen M. Goorin,Richard Gorlick,Holcombe E. Grier,Juliet Hale,Kirsten Sundby Hall,Jendrik Hardes,Douglas S. Hawkins,Knut Helmke,Pancras C.W. Hogendoorn,Michael S. Isakoff,Katherine A. Janeway,Heribert Jürgens,Leo Kager,Thomas Kühne,Ching C. Lau,Patrick J. Leavey,Stephen L. Lessnick,Leo Mascarenhas,Paul A. Meyers,Hubert Mottl,Michaela Nathrath,Zsuzsanna Papai,R. Lor Randall,Peter Reichardt,Marleen Renard,Akmal Safwat,Cindy L. Schwartz,Michael C. Stevens,Sandra J. Strauss,Lisa A. Teot,Mathias Werner,Matthew R. Sydes,Jeremy Whelan +53 more
TL;DR: The EURAMOS-1 results do not support the addition of ifosfamide and etoposide in patients with poorly responding osteosarcoma, and the primary outcome measure was event-free survival measured in the intention-to-treat population.
Journal ArticleDOI
Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency
Michal Kovac,Claudia Blattmann,Sebastian Ribi,Jan Smida,Nikola S. Mueller,Florian Engert,Francesc Castro-Giner,Joachim Weischenfeldt,Monika Kovacova,Andreas H. Krieg,Dimosthenis Andreou,Per-Ulf Tunn,Hans Roland Dürr,Hans Rechl,Klaus-Dieter Schaser,Ingo Melcher,Stefan Burdach,Andreas E. Kulozik,Katja Specht,Karl Heinimann,Simone Fulda,Simone Fulda,Stefan S. Bielack,Gernot Jundt,Ian Tomlinson,Jan O. Korbel,Michaela Nathrath,Daniel Baumhoer +27 more
TL;DR: It is implied that multiple oncogenic pathways drive chromosomal instability during osteosarcoma evolution and result in the acquisition of BRCA-like traits, which could be therapeutically exploited.
Journal ArticleDOI
Next-generation personalised medicine for high-risk paediatric cancer patients – The INFORM pilot study
Barbara C. Worst,Barbara C. Worst,Cornelis M. van Tilburg,Gnana Prakash Balasubramanian,Petra Fiesel,Petra Fiesel,Ruth Witt,Angelika Freitag,Miream Boudalil,Miream Boudalil,Christopher Previti,Stephan Wolf,Sabine Schmidt,Sasithorn Chotewutmontri,Melanie Bewerunge-Hudler,Matthias Schick,Matthias Schlesner,Barbara Hutter,Lenka A. Taylor,Tobias Borst,Christian Sutter,Claus R. Bartram,Till Milde,Till Milde,Elke Pfaff,Elke Pfaff,Andreas E. Kulozik,Arend von Stackelberg,Roland Meisel,Arndt Borkhardt,Dirk Reinhardt,Jan-Henning Klusmann,Gudrun Fleischhack,Stephan Tippelt,Uta Dirksen,Heribert Jürgens,Christof M. Kramm,André O. von Bueren,Frank Westermann,Matthias Fischer,Matthias Fischer,Birgit Burkhardt,Wilhelm Wößmann,Michaela Nathrath,Stefan S. Bielack,Michael C. Frühwald,Simone Fulda,Thomas Klingebiel,Ewa Koscielniak,Matthias Schwab,Matthias Schwab,Roman Tremmel,Roman Tremmel,Pablo Hernáiz Driever,Johannes H. Schulte,Benedikt Brors,Andreas von Deimling,Andreas von Deimling,Peter Lichter,Angelika Eggert,David Capper,David Capper,Stefan M. Pfister,Stefan M. Pfister,David T.W. Jones,Olaf Witt,Olaf Witt +66 more
TL;DR: This study demonstrates the feasibility of comprehensive, real-time molecular profiling for high-risk paediatric cancer patients and expands upon previous personalised oncology endeavors, and presents a model with considerable interest and practical relevance in the burgeoning era of personalised medicine.
Journal ArticleDOI
Adoptive Transfer of Epstein-Barr Virus (EBV) Nuclear Antigen 1–Specific T Cells As Treatment for EBV Reactivation and Lymphoproliferative Disorders After Allogeneic Stem-Cell Transplantation
Vanya Icheva,Simone Kayser,Daniel Wolff,Sebastian Tuve,Christina Kyzirakos,Wolfgang Bethge,Johann Greil,Michael H. Albert,Wolfgang Schwinger,Michaela Nathrath,Michael Schumm,Stefan Stevanovic,Rupert Handgretinger,Peter Lang,Tobias Feuchtinger +14 more
TL;DR: Adoptive ex vivo transfer of EBNA-1-specific T cells is a feasible and well-tolerated therapeutic option, representing a fast and efficient procedure to achieve reconstitution of antiviral T-cell immunity after SCT.