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Francesco Sansone

Researcher at University of Parma

Publications -  141
Citations -  5397

Francesco Sansone is an academic researcher from University of Parma. The author has contributed to research in topics: Calixarene & Supramolecular chemistry. The author has an hindex of 37, co-authored 135 publications receiving 4977 citations. Previous affiliations of Francesco Sansone include Eni & Wroclaw University of Environmental and Life Sciences.

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Multivalent glycoconjugates as anti-pathogenic agents

TL;DR: By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance.
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Calixarene-based multivalent ligands

TL;DR: This tutorial review illustrates the fundamental aspects of multivalency and the properties of calixarene-based multivalent ligands in lectin binding and inhibition, DNA condensation and cell transfection, protein surface recognition, self-assembly, crystal engineering, and nanofabrication.
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Peptido- and glycocalixarenes: playing with hydrogen bonds around hydrophobic cavities.

TL;DR: Glycocalix[4]arenes show the phenomenon of multivalency in their binding to specific lectins, and those bearing thiourea spacers between the calix[ 4]arene scaffold and the sugar units are able to bind aromatic carboxylates and phosphates, making them attractive as novel site specific drug delivery systems.
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DNA condensation and cell transfection properties of guanidinium calixarenes: dependence on macrocycle lipophilicity, size, and conformation.

TL;DR: Atomic force microscopy studies indicate that upon DNA binding the hydrophobic association of the lipophilic chains of cone guanidinium calix[4]arenes drives the formation of intramolecular DNA condensates, characterized by DNA loops emerging from a dense core.
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Calixarenes: from biomimetic receptors to multivalent ligands for biomolecular recognition

TL;DR: Examples of calixarene macrocycles spanning the recognition of small peptides and carbohydrates to ion transport through membranes, biomimetic catalysis, DNA condensation and cell transfection, protein binding, sensing and inhibition are illustrated.