F
Franciska Haneveld
Researcher at University of Amsterdam
Publications - 9
Citations - 1883
Franciska Haneveld is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Neuroblastoma & N-Myc. The author has an hindex of 7, co-authored 8 publications receiving 1551 citations.
Papers
More filters
Journal ArticleDOI
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
Jan J. Molenaar,Jan Koster,Danny A. Zwijnenburg,Peter van Sluis,Linda J. Valentijn,Ida van der Ploeg,Mohamed Hamdi,Johan van Nes,Bart A. Westerman,Jennemiek van Arkel,Marli E. Ebus,Franciska Haneveld,Arjan Lakeman,Linda Schild,Piet Molenaar,Peter Stroeken,Max M. van Noesel,Ingrid Øra,Ingrid Øra,Evan E. Santo,Huib N. Caron,Ellen M. Westerhout,Rogier Versteeg +22 more
TL;DR: The genomic landscape of neuroblastoma reveals two novel molecular defects, chromothripsis and neuritogenesis gene alterations, which frequently occur in high-risk tumours.
Journal ArticleDOI
LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
Jan J. Molenaar,Raquel Domingo-Fernández,Marli E. Ebus,Sven Lindner,Jan Koster,Ksenjia Drabek,Pieter Mestdagh,Peter van Sluis,Linda J. Valentijn,Johan van Nes,Marloes Broekmans,Franciska Haneveld,Richard Volckmann,Isabella Bray,Lukas C. Heukamp,Annika Sprüssel,Theresa Thor,Kristina Kieckbusch,Ludger Klein-Hitpass,Matthias Fischer,Jo Vandesompele,Alexander Schramm,Max M. van Noesel,Luigi Varesio,Franki Speleman,Angelika Eggert,Raymond L. Stallings,Huib N. Caron,Rogier Versteeg,Johannes H. Schulte +29 more
TL;DR: It is reported that LIN28B showed genomic aberrations and extensive overexpression in high-risk neuroblastoma compared to several other tumor entities and normal tissues and was an independent risk factor for adverse outcome in neuroblastomas.
Journal ArticleDOI
Neuroblastoma is composed of two super-enhancer-associated differentiation states
Tim van Groningen,Jan Koster,Linda J. Valentijn,Danny A. Zwijnenburg,Nurdan Akogul,Nancy E. Hasselt,Marloes Broekmans,Franciska Haneveld,Natalia E Nowakowska,Johannes Bras,Carel J. M. van Noesel,Aldo Jongejan,Antoine H. C. van Kampen,Linda Koster,Frank Baas,Lianne van Dijk-Kerkhoven,Margriet Huizer-Smit,Maria C. Lecca,Alvin Chan,Arjan Lakeman,Piet Molenaar,Richard Volckmann,Ellen M. Westerhout,Mohamed Hamdi,Peter van Sluis,Marli E. Ebus,Marli E. Ebus,Jan J. Molenaar,Jan J. Molenaar,Godelieve A.M. Tytgat,Bart A. Westerman,Johan van Nes,Rogier Versteeg +32 more
TL;DR: It is shown that most neuroblastomas include two types of tumor cells with divergent gene expression profiles, and two super-enhancer-associated TF networks thus dominate epigenetic control of neuroblastoma and shape intratumoral heterogeneity.
Journal ArticleDOI
Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification
Linda J. Valentijn,Jan Koster,Franciska Haneveld,Rachida Ait Aissa,Peter van Sluis,Marloes Broekmans,Jan J. Molenaar,Johan van Nes,Rogier Versteeg +8 more
TL;DR: The functional MYCN-157 signature recognizes classical neuroblastoma with MYCN amplification, as well as a newly identified group marked by MYCN protein stabilization, suggesting stabilization of MYCN at the protein level.
Journal ArticleDOI
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma.
Tim van Groningen,Nurdan Akogul,Ellen M. Westerhout,Alvin Chan,Nancy E. Hasselt,Danny A. Zwijnenburg,Marloes Broekmans,Peter Stroeken,Franciska Haneveld,Gerrit K. J. Hooijer,C. Dilara Savci-Heijink,Arjan Lakeman,Richard Volckmann,Peter van Sluis,Linda J. Valentijn,Jan Koster,Rogier Versteeg,Johan van Nes +17 more
TL;DR: This work unravels how a NOTCH3 intracellular domain reprogrammed the ADRN transcriptional landscape towards a MES state and elucidate a swift transdifferentiation between two semi-stable epigenetic cellular states.