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Bart A. Westerman
Researcher at VU University Medical Center
Publications - 52
Citations - 3596
Bart A. Westerman is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 21, co-authored 43 publications receiving 2698 citations. Previous affiliations of Bart A. Westerman include University of Amsterdam & Netherlands Cancer Institute.
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Journal ArticleDOI
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
Jan J. Molenaar,Jan Koster,Danny A. Zwijnenburg,Peter van Sluis,Linda J. Valentijn,Ida van der Ploeg,Mohamed Hamdi,Johan van Nes,Bart A. Westerman,Jennemiek van Arkel,Marli E. Ebus,Franciska Haneveld,Arjan Lakeman,Linda Schild,Piet Molenaar,Peter Stroeken,Max M. van Noesel,Ingrid Øra,Ingrid Øra,Evan E. Santo,Huib N. Caron,Ellen M. Westerhout,Rogier Versteeg +22 more
TL;DR: The genomic landscape of neuroblastoma reveals two novel molecular defects, chromothripsis and neuritogenesis gene alterations, which frequently occur in high-risk tumours.
Journal ArticleDOI
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics
Myron G. Best,Nik Sol,Irsan E. Kooi,Jihane Tannous,Bart A. Westerman,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Jan Koster,Bauke Ylstra,Najim Ameziane,Josephine C. Dorsman,Egbert F. Smit,Henk M.W. Verheul,David P. Noske,Jaap C. Reijneveld,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Bakhos A. Tannous,Pieter Wesseling,Pieter Wesseling,Thomas Wurdinger,Thomas Wurdinger +23 more
TL;DR: The results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based “liquid biopsies”.
Journal ArticleDOI
Neuroblastoma is composed of two super-enhancer-associated differentiation states
Tim van Groningen,Jan Koster,Linda J. Valentijn,Danny A. Zwijnenburg,Nurdan Akogul,Nancy E. Hasselt,Marloes Broekmans,Franciska Haneveld,Natalia E Nowakowska,Johannes Bras,Carel J. M. van Noesel,Aldo Jongejan,Antoine H. C. van Kampen,Linda Koster,Frank Baas,Lianne van Dijk-Kerkhoven,Margriet Huizer-Smit,Maria C. Lecca,Alvin Chan,Arjan Lakeman,Piet Molenaar,Richard Volckmann,Ellen M. Westerhout,Mohamed Hamdi,Peter van Sluis,Marli E. Ebus,Marli E. Ebus,Jan J. Molenaar,Jan J. Molenaar,Godelieve A.M. Tytgat,Bart A. Westerman,Johan van Nes,Rogier Versteeg +32 more
TL;DR: It is shown that most neuroblastomas include two types of tumor cells with divergent gene expression profiles, and two super-enhancer-associated TF networks thus dominate epigenetic control of neuroblastoma and shape intratumoral heterogeneity.
Journal ArticleDOI
Longitudinal molecular trajectories of diffuse glioma in adults
Floris P. Barthel,Kevin C. Johnson,Frederick S. Varn,Anzhela D. Moskalik,Georgette Tanner,Emre Kocakavuk,Kevin J. Anderson,Olajide Abiola,Kenneth Aldape,Kristin Alfaro,Donát Alpár,Donát Alpár,Samirkumar B. Amin,David M. Ashley,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Jill S. Barnholtz-Sloan,Rameen Beroukhim,Rameen Beroukhim,Christoph Bock,Christoph Bock,Priscilla K. Brastianos,Daniel J. Brat,Andrew R Brodbelt,Alexander F. Bruns,Ketan R. Bulsara,Aruna Chakrabarty,Arnab Chakravarti,Jeffrey H. Chuang,Elizabeth B. Claus,Elizabeth B. Claus,Elizabeth J. Cochran,Jennifer Connelly,Joseph F. Costello,Gaetano Finocchiaro,Michael N. C. Fletcher,Pim J. French,Hui K Gan,Hui K Gan,Mark R. Gilbert,Peter Gould,Matthew R. Grimmer,Antonio Iavarone,Azzam Ismail,Michael D. Jenkinson,Mustafa Khasraw,Hoon Kim,Mathilde C.M. Kouwenhoven,Peter S. LaViolette,Meihong Li,Peter Lichter,Keith L. Ligon,Keith L. Ligon,Allison Lowman,Tathiane M. Malta,Tali Mazor,Kerrie L. McDonald,Annette M. Molinaro,Do-Hyun Nam,Naema Nayyar,Ho Keung Ng,Chew Yee Ngan,Simone P. Niclou,Johanna M. Niers,Houtan Noushmehr,Javad Noorbakhsh,D. Ryan Ormond,Chul-Kee Park,Laila M. Poisson,Raul Rabadan,Raul Rabadan,Bernhard Radlwimmer,Ganesh Rao,Guido Reifenberger,Jason K. Sa,Michael Schuster,Brian L. Shaw,Susan C Short,Peter A. E. Sillevis Smitt,Andrew E. Sloan,Andrew E. Sloan,Marion Smits,Hiromichi Suzuki,Ghazaleh Tabatabai,Erwin G. Van Meir,Colin Watts,Michael Weller,Pieter Wesseling,Bart A. Westerman,Georg Widhalm,Adelheid Woehrer,W. K. Alfred Yung,Gelareh Zadeh,Jason T. Huse,John de Groot,Lucy F. Stead,Roel G.W. Verhaak +96 more
TL;DR: The results suggest that the strongest selective pressures occur during early glioma development and that current therapies shape this evolution in a largely stochastic manner.
Journal ArticleDOI
ZNF423 Is Critically Required for Retinoic Acid-Induced Differentiation and Is a Marker of Neuroblastoma Outcome
Sidong Huang,Jamila Laoukili,Mirjam T. Epping,Jan Koster,Michael Hölzel,Bart A. Westerman,Wouter Nijkamp,Akiko Hata,Shahab Asgharzadeh,Robert C. Seeger,Rogier Versteeg,Roderick L. Beijersbergen,René Bernards +12 more
TL;DR: Using a large-scale RNA interference-based genetic screen, ZNF423 is identified as a component critically required for retinoic acid (RA)-induced differentiation and shown to be associated with poor disease outcome in neuroblastoma patients.