P
Peter Stroeken
Researcher at University of Amsterdam
Publications - 6
Citations - 1004
Peter Stroeken is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Neuroblastoma & Gene. The author has an hindex of 3, co-authored 5 publications receiving 858 citations.
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Journal ArticleDOI
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
Jan J. Molenaar,Jan Koster,Danny A. Zwijnenburg,Peter van Sluis,Linda J. Valentijn,Ida van der Ploeg,Mohamed Hamdi,Johan van Nes,Bart A. Westerman,Jennemiek van Arkel,Marli E. Ebus,Franciska Haneveld,Arjan Lakeman,Linda Schild,Piet Molenaar,Peter Stroeken,Max M. van Noesel,Ingrid Øra,Ingrid Øra,Evan E. Santo,Huib N. Caron,Ellen M. Westerhout,Rogier Versteeg +22 more
TL;DR: The genomic landscape of neuroblastoma reveals two novel molecular defects, chromothripsis and neuritogenesis gene alterations, which frequently occur in high-risk tumours.
Journal ArticleDOI
FOXO3a Is A Major Target Of Inactivation By PI3K/AKT Signaling In Aggressive Neuroblastoma
TL;DR: It is indicated that expression of FOXO3a and its targets offer useful prognostic markers as well as biomarkers for PI3K/AKT inhibitor efficacy in neuroblastoma.
Journal ArticleDOI
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma.
Tim van Groningen,Nurdan Akogul,Ellen M. Westerhout,Alvin Chan,Nancy E. Hasselt,Danny A. Zwijnenburg,Marloes Broekmans,Peter Stroeken,Franciska Haneveld,Gerrit K. J. Hooijer,C. Dilara Savci-Heijink,Arjan Lakeman,Richard Volckmann,Peter van Sluis,Linda J. Valentijn,Jan Koster,Rogier Versteeg,Johan van Nes +17 more
TL;DR: This work unravels how a NOTCH3 intracellular domain reprogrammed the ADRN transcriptional landscape towards a MES state and elucidate a swift transdifferentiation between two semi-stable epigenetic cellular states.
Posted ContentDOI
An immature subset of neuroblastoma cells synthesizes retinoic acid and depends on this metabolite
van Groningen T,Niklasson Cu,Alvin Chan,Nurdan Akogul,Ellen M. Westerhout,von Stedingk K,von Stedingk K,Mohamed Hamdi,Linda J. Valentijn,Sofie Mohlin,Peter Stroeken,Nancy E. Hasselt,Franciska Haneveld,Arjan Lakeman,Danny A. Zwijnenburg,van Sluis P,Daniel Bexell,Igor Adameyko,Selina Jansky,Frank Westermann,Caroline Wigerup,Sven Påhlman,Jan Koster,Rogier Versteeg,van Nes J +24 more
TL;DR: In this article, it was shown that immature mesenchymal (MES) cells synthesize retinoic acid (RA) and require this metabolite for proliferation and motility.
Journal ArticleDOI
FOXO3A-Short is a Novel Regulator of Non-Oxidative Glucose Metabolism Associated with Human Longevity
Evan E. Santo,Rasmus Ribel-Madsen,Peter Stroeken,Vincent C.J. de Boer,Ninna S. Hansen,Maaike Commandeur,Allan Vaag,Rogier Versteeg,Jihye Paik,Ellen M. Westerhout +9 more
TL;DR: It is found that the rs9400239 variant influences the stability and functionality of the primarily nuclear protein(s) encoded by the FOXO3A-S mRNA, which is highly expressed in skeletal muscle and has very limited expression in other tissues.