F
François M. Lemoine
Researcher at University of Paris
Publications - 100
Citations - 4027
François M. Lemoine is an academic researcher from University of Paris. The author has contributed to research in topics: Bone marrow & Haematopoiesis. The author has an hindex of 33, co-authored 99 publications receiving 3691 citations. Previous affiliations of François M. Lemoine include University of Paris-Sud & Centre national de la recherche scientifique.
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Journal ArticleDOI
PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer
Cécile Badoual,Stéphane Hans,Nathalie Merillon,Cordelia Van Ryswick,Patrice Ravel,Nadine Benhamouda,Emeline Levionnois,Mevyn Nizard,Ali Si-Mohamed,Nicolas Besnier,Alain Gey,Rinat Rotem-Yehudar,Hélène Péré,Thi Tran,Coralie L. Guerin,Anne Chauvat,Estelle Dransart,Cécile Alanio,Sebastien Albert,Béatrix Barry,Federico Sandoval,Françoise Quintin-Colonna,Patrick Bruneval,Wolf H. Fridman,François M. Lemoine,Stéphane Oudard,Ludger Johannes,Daniel Olive,Daniel Brasnu,Eric Tartour +29 more
TL;DR: These findings prompt a need to revisit the significance of PD-1-infiltrating T cells in cancer, where it is suggested thatPD-1 detection may reflect a previous immune response against tumors that might be reactivated by PD- 1/PD-L1 blockade.
Journal ArticleDOI
Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects
Christophe Borg,Magali Terme,Julien Taieb,Cédric Ménard,Caroline Flament,Caroline Robert,Koji Maruyama,Koji Maruyama,Hiro Wakasugi,Eric Angevin,Kris Thielemans,Axel Le Cesne,Véronique Chung-Scott,Vladimir Lazar,Isabelle Tchou,Florent Crépineau,François M. Lemoine,Jacky Bernard,Jonhantan A. Fletcher,Ali G. Turhan,Jean-Yves Blay,Alain Spatz,J.F. Emile,Michael Heinrich,Salah Mecheri,Thomas Tursz,Laurence Zitvogel +26 more
TL;DR: It is shown that Gleevec can act on host DCs to promote NK cell activation, and tumors that are refractory to the antiproliferative effects of GLeevec in vitro responded to Glee Vec in vivo in an NK cell-dependent manner.
Journal ArticleDOI
Identification of CD8+CD25+Foxp3+ suppressive T cells in colorectal cancer tissue
Nathalie Chaput,Samy Louafi,Armelle Bardier,Frédéric Charlotte,Jean-Christophe Vaillant,Fabrice Menegaux,Michelle Rosenzwajg,François M. Lemoine,David Klatzmann,Julien Taieb +9 more
TL;DR: A new regulatory T cell population (CD8+Foxp3+) in colorectal tumours is identified and demonstrated strong immunosuppressive properties in vitro, suggesting that these cells may contribute to tumoral immune escape and disease progression.
Journal ArticleDOI
GILZ expression in human dendritic cells redirects their maturation and prevents antigen-specific T lymphocyte response
Nicolas Cohen,Nicolas Cohen,Enguerran Mouly,Enguerran Mouly,Haifa Hamdi,Haifa Hamdi,M C Maillot,M C Maillot,Marc Pallardy,Marc Pallardy,Véronique Godot,Véronique Godot,Francis Capel,Francis Capel,Axel Balian,Axel Balian,Sylvie Naveau,Sylvie Naveau,Pierre Galanaud,Pierre Galanaud,François M. Lemoine,François M. Lemoine,Dominique Emilie,Dominique Emilie +23 more
TL;DR: Induction of GILZ (GC-induced leucine zipper) is involved in the inhibition of antigen-presenting dendritic cells' ability to stimulate T lymphocytes, and IL-10, GCs, and TGFbeta share this mechanism for influencing DC functions and the balance between immune response and tolerance.
Journal ArticleDOI
Highly purified primitive hematopoietic stem cells are PML-RARA negative and generate nonclonal progenitors in acute promyelocytic leukemia
Ali G. Turhan,François M. Lemoine,C Debert,M L Bonnet,Claude Baillou,F Picard,Elisabeth Macintyre,Bruno Varet +7 more
TL;DR: It is suggested that the primitive hematopoietic stem cells as defined by the CD34+/CD38- antigens are not involved by the neoplastic process in APL, and may have important implications for autografting strategies of retinoic acid/chemotherapy-resistant or relapsed patients.