F
Frank R. DeLeo
Researcher at National Institutes of Health
Publications - 210
Citations - 28910
Frank R. DeLeo is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Staphylococcus aureus & Innate immune system. The author has an hindex of 86, co-authored 206 publications receiving 26462 citations. Previous affiliations of Frank R. DeLeo include Montana State University & University of Iowa.
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Journal ArticleDOI
Waves of resistance: Staphylococcus aureus in the antibiotic era
Henry F. Chambers,Frank R. DeLeo +1 more
TL;DR: The molecular epidemiology of the epidemic waves of peniillin- and methicillin-resistant strains of S. aureus that have occurred since 1940 are reviewed, with a focus on the clinical and molecular epidemiological of CA-MRSA.
Journal ArticleDOI
Community-associated meticillin-resistant Staphylococcus aureus
TL;DR: A review of the most up-to-date knowledge and a perspective for the future prophylaxis or new treatments for CA-MRSA infections is provided in this paper.
Journal ArticleDOI
STAT3 Mutations in the Hyper-IgE Syndrome
Steven M. Holland,Frank R. DeLeo,Houda Elloumi,Amy P. Hsu,Gulbu Uzel,Nina N. Brodsky,Alexandra F. Freeman,Andrew P. Demidowich,Joie Davis,Maria L. Turner,Victoria L. Anderson,Dirk Darnell,Pamela Welch,Douglas B. Kuhns,David M. Frucht,Harry L. Malech,John I. Gallin,Scott D. Kobayashi,Adeline R. Whitney,Jovanka M. Voyich,James M. Musser,Cristina Woellner,Alejandro A. Schäffer,Jennifer M. Puck,Bodo Grimbacher +24 more
TL;DR: Mutations in STAT3 underlie sporadic and dominant forms of the hyper-IgE syndrome, an immunodeficiency syndrome involving increased innate immune response, recurrent infections, and complex somatic features.
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Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA
Rong Wang,Kevin R. Braughton,Dorothee Kretschmer,Thanh-Huy L. Bach,Shu Y. Queck,Min Li,Adam D. Kennedy,David W. Dorward,Seymour J. Klebanoff,Andreas Peschel,Frank R. DeLeo,Michael Otto +11 more
TL;DR: A previously uncharacterized set of S. aureus virulence factors are revealed that account at least in part for the enhanced virulence of CA-MRSA.
Journal ArticleDOI
Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system
Cuong Vuong,Jovanka M. Voyich,Elizabeth R. Fischer,Kevin R. Braughton,Adeline R. Whitney,Frank R. DeLeo,Michael Otto +6 more
TL;DR: Scanning electron microscopy is used to demonstrate that the exopolysaccharide intercellular adhesin (PIA) resides in fibrous strands on the bacterial cell surface, and that lack of PIA production results in complete loss of the extracellular matrix material that has been suggested to mediate immune evasion.