F
Frederik Dethloff
Researcher at Max Planck Society
Publications - 23
Citations - 605
Frederik Dethloff is an academic researcher from Max Planck Society. The author has contributed to research in topics: Autophagy & Metabolite. The author has an hindex of 10, co-authored 20 publications receiving 358 citations.
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Book ChapterDOI
Profiling Methods to Identify Cold-Regulated Primary Metabolites Using Gas Chromatography Coupled to Mass Spectrometry
Frederik Dethloff,Alexander Erban,Isabel Orf,Jessica Alpers,Ines Fehrle,Olga Beine-Golovchuk,Stefanie Schmidt,Jens Schwachtje,Joachim Kopka +8 more
TL;DR: The method has two applications: the rapid screening for changes of relative metabolite pools sizes under temperature stress and the verification of cold-regulated metabolites by exact quantification using a GC-MS protocol with extended internal and external standardization.
Journal ArticleDOI
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion.
Silvia Martinelli,Elmira Anderzhanova,Elmira Anderzhanova,Thomas Bajaj,Svenja Wiechmann,Frederik Dethloff,Katja Weckmann,Daniel E. Heinz,Daniel E. Heinz,Tim Ebert,Jakob Hartmann,Thomas M. Geiger,Michael Döngi,Kathrin Hafner,Max L. Pöhlmann,Lee Jollans,Alexandra Philipsen,Susanne Schmidt,Ulrike Schmidt,Ulrike Schmidt,Ulrike Schmidt,Giuseppina Maccarrone,Valentin Stein,Felix Hausch,Christoph W. Turck,Mathias V. Schmidt,Anne-Kathrin Gellner,Bernhard Kuster,Nils C. Gassen,Nils C. Gassen +29 more
TL;DR: In this paper, stress-enhanced matrix metalloproteinase 9 (MMP9) secretion increases the cleavage of pro-brain-derived neurotrophic factor (proBDNF) to its mature form.
Journal ArticleDOI
The REIL1 and REIL2 Proteins of Arabidopsis thaliana Are Required for Leaf Growth in the Cold
TL;DR: The conserved correlations point to a role of A. thaliana REIL proteins in the maturation of the eukaryotic ribosomal 60S subunit, supported by heterologous complementation of the cold-induced growth defect of the yeast Δrei1 deletion.
Book ChapterDOI
Quantification of stable isotope label in metabolites via mass spectrometry.
TL;DR: The use of the CORRECTOR program is described, which utilizes matrix calculations to correct mass spectral data from stable isotope labelling experiments for the distorting effect of naturally occurring stable isotopes (NOIs).
Journal ArticleDOI
Ketamine's Effects on the Glutamatergic and GABAergic Systems: A Proteomics and Metabolomics Study in Mice.
Katja Weckmann,Katja Weckmann,Michael J. Deery,Julie Howard,Renata Feret,John M. Asara,Frederik Dethloff,Michaela D. Filiou,Christiana Labermaier,Giuseppina Maccarrone,Kathryn S. Lilley,Marianne Mueller,Christoph W. Turck +12 more
TL;DR: The data indicate that ketamine impacts the AMPAR subunit Gria2 and results in decreased GABAergic inhibitory neurotransmission leading to increased excitatory neuronal activity.