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Fuller W. Bazer

Researcher at Texas A&M University

Publications -  833
Citations -  50274

Fuller W. Bazer is an academic researcher from Texas A&M University. The author has contributed to research in topics: Conceptus & Endometrium. The author has an hindex of 109, co-authored 803 publications receiving 46194 citations. Previous affiliations of Fuller W. Bazer include Texas A&M University System & Auburn University.

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Uterine MHC Class I Molecules and β2-Microglobulin Are Regulated by Progesterone and Conceptus Interferons during Pig Pregnancy

TL;DR: Cell-type specific regulation of SLA and β2m genes by progesterone and IFNs suggests that placental secretions control expression of immune regulatory molecules on uterine cells to provide an immunologically favorable environment for survival of the fetal-placental semiallograft.
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Interferon stimulated gene 15 conjugates to endometrial cytosolic proteins and is expressed at the uterine-placental interface throughout pregnancy in sheep.

TL;DR: These results are the first to show in vivo regulation of ISG15 function (i.e. conjugation to target proteins) by a type I IFN in the uterus of any species and thatISG15 is expressed at contacts between the placenta and uterus when trophectoderm no longer produces IFNtau.
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Putrescine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells.

TL;DR: Results indicate that putrescine promotes cell proliferation and protein synthesis in a dose- and time-dependent manner, which was inhibited by difluoro-methylornithine (an inhibitor of ornithine decarboxylase), and reveals a novel and important role for putresCine in regulating the mTOR signaling pathway in porcine placental cells.
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Biochemical aspects of conceptus–endometrial interactions

TL;DR: In addition to estrogens of conceptus origin, calcium and prostaglandins PGF2 alpha and E2 may affect the uterine vasculature, water and electrolyte transport, capillary permeability, conceptus steroid production, and related events during pregnancy.
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Farm Animal Research in Crisis

TL;DR: A direct comparison between USDA and DHHS budgets illustrates the huge disparity in total budget available for research grants focused on animal agriculture, about 1/918th that for human health.