S
So-Youn Shin
Researcher at Wellcome Trust Sanger Institute
Publications - 49
Citations - 10970
So-Youn Shin is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 34, co-authored 48 publications receiving 9873 citations. Previous affiliations of So-Youn Shin include University of Bristol.
Papers
More filters
Journal ArticleDOI
An atlas of genetic influences on human blood metabolites
So-Youn Shin,Eric B. Fauman,Ann-Kristin Petersen,Jan Krumsiek,Rita Santos,Jie Huang,Matthias Arnold,Idil Erte,Vincenzo Forgetta,Tsun-Po Yang,Klaudia Walter,Cristina Menni,Lu Chen,Lu Chen,Louella Vasquez,Ana M. Valdes,Ana M. Valdes,Craig L. Hyde,Vicky Wang,Daniel Ziemek,Phoebe M. Roberts,Li Xi,Elin Grundberg,Melanie Waldenberger,J. Brent Richards,Robert P. Mohney,Michael V. Milburn,Sally John,Jeff K. Trimmer,Fabian J. Theis,John P. Overington,Karsten Suhre,M. Julia Brosnan,Christian Gieger,Gabi Kastenmüller,Tim D. Spector,Nicole Soranzo +36 more
TL;DR: The most comprehensive exploration of genetic loci influencing human metabolism thus far, comprising 7,824 adult individuals from 2 European population studies, is reported, reporting genome-wide significant associations at 145 metabolic loci and their biochemical connectivity with more than 400 metabolites in human blood.
Journal ArticleDOI
Human metabolic individuality in biomedical and pharmaceutical research
Karsten Suhre,So-Youn Shin,Ann-Kristin Petersen,Robert P. Mohney,David Meredith,Brigitte Wägele,Elisabeth Altmaier,Panos Deloukas,Jeanette Erdmann,Elin Grundberg,Elin Grundberg,Christopher J Hammond,Martin Hrabé de Angelis,Gabi Kastenmüller,Anna Köttgen,Florian Kronenberg,Massimo Mangino,Christa Meisinger,Thomas Meitinger,Hans-Werner Mewes,Michael V. Milburn,Cornelia Prehn,Johannes Raffler,Janina S. Ried,Werner Römisch-Margl,Nilesh J. Samani,Kerrin S. Small,H.-Erich Wichmann,Guangju Zhai,Thomas Illig,Tim D. Spector,Jerzy Adamski,Nicole Soranzo,Christian Gieger +33 more
TL;DR: A comprehensive analysis of genotype-dependent metabolic phenotypes using a genome-wide association study with non-targeted metabolomics to identify genetic loci associated with blood metabolite concentrations and generates many new hypotheses for biomedical and pharmaceutical research.
The UK10K project identifies rare variants in health and disease
Klaudia Walter,Josine L. Min,Jie Huang,Lucy Crooks,Yasin Memari,Shane A. McCarthy,John R. B. Perry,ChangJiang Xu,Marta Futema,Daniel Lawson,Valentina Iotchkova,Stephan Schiffels,Audrey E. Hendricks,Petr Danecek,Rui Li,James A B Floyd,Louise V. Wain,Inês Barroso,Steve E. Humphries,Matthew E. Hurles,Eleftheria Zeggini,Jeffrey C. Barrett,Vincent Plagnol,J. Brent Richards,Celia M. T. Greenwood,Nicholas J. Timpson,Richard Durbin,Nicole Soranzo,Senduran Bala,Peter Clapham,Guy Coates,Tony Cox,Allan Daly,Yuanping Du,Sarah Edkins,Peter R. Ellis,Paul Flicek,Xiaosen Guo,Xueqin Guo,Liren Huang,David K. Jackson,Christopher J. Joyce,Thomas Keane,Anja Kolb-Kokocinski,Cordelia Langford,Yingrui Li,Jieqin Liang,Hong Lin,Ryan Liu,John Maslen,Dawn Muddyman,Michael A. Quail,Jim Stalker,Jianping Sun,Jing Tian,Guangbiao Wang,Jun Wang,Yu Wang,Kim Wong,Pingbo Zhang,Ewan Birney,Chris Boustred,Lu Chen,Gail Clement,Massimiliano Cocca,George Davey Smith,Ian N.M. Day,Aaron G. Day-Williams,Thomas A. Down,Ian Dunham,David M. Evans,Tom R. Gaunt,Matthias Geihs,Deborah J. Hart,Bryan Howie,Tim Hubbard,Pirro G. Hysi,Yalda Jamshidi,Konrad J. Karczewski,John P. Kemp,Genevieve Lachance,Monkol Lek,Margarida C. Lopes,Daniel G. MacArthur,Jonathan Marchini,Massimo Mangino,Iain Mathieson,Sarah Metrustry,Alireza Moayyeri,Kate Northstone,Kalliope Panoutsopoulou,Lavinia Paternoster,Lydia Quaye,Susan M. Ring,Graham R. S. Ritchie,Hashem A. Shihab,So-Youn Shin,Kerrin S. Small,María Soler Artigas,Lorraine Southam,Tim D. Spector,Beate St Pourcain,Gabriela L. Surdulescu,Ioanna Tachmazidou,Martin D. Tobin,Ana M. Valdes,Peter M. Visscher,Kirsten J. Ward,Scott Wilson,Jian Yang,Feng Zhang,Hou-Feng Zheng,Richard Anney,Muhammad Ayub,Douglas Blackwood,Patrick Bolton,Gerome Breen,David A. Collier,Nicholas John Craddock,Sarah Curran,David Curtis,Louise Gallagher,Daniel H. Geschwind,Hugh Gurling,Peter Holmans,Irene Lee,Jouko Lönnqvist,Peter McGuffin,Andrew M. McIntosh,Andrew McKechanie,Andrew McQuillin,James Morris,Michael Conlon O'Donovan,Michael John Owen,Aarno Palotie,Jeremy R. Parr,Tiina Paunio,Olli Pietiläinen,Karola Rehnström,Sally I. Sharp,David Skuse,David St Clair,Jaana Suvisaari,James T.R. Walters,Hywel Williams,Elena G. Bochukova,Rebecca Bounds,Anna F. Dominiczak,I. Sadaf Farooqi,Julia M. Keogh,Gaëlle Marenne,Andrew D. Morris,Stephen O'Rahilly,David J. Porteous,Blair H. Smith,Eleanor Wheeler,Saeed Al Turki,Carl A. Anderson,Dinu Antony,PL Beales,Jamie Bentham,Shoumo Bhattacharya,Mattia Calissano,Keren J. Carss,Krishna Chatterjee,Sebahattin Cirak,Catherine Cosgrove,David R. FitzPatrick,A. Reghan Foley,Christopher S. Franklin,Detelina Grozeva,Hannah M. Mitchison,Francesco Muntoni,Alexandros Onoufriadis,Victoria E. R. Parker,Felicity Payne,F. Lucy Raymond,Nicola D. Roberts,David B. Savage,Peter J. Scambler,Miriam Schmidts,Nadia Schoenmakers,Robert K. Semple,Eva Goncalves Serra,Olivera Spasic-Boskovic,Elizabeth Stevens,Margriet van Kogelenberg,Parthiban Vijayarangakannan,Kathleen A. Williamson,Crispian Wilson,Tamieka Whyte,Antonio Ciampi,Karim Oualkacha,Martin Bobrow,Heather Griffin,Jane Kaye,Karen Kennedy,Alastair Kent,Carol Smee,R. Charlton,Rosemary Ekong,Farrah Khawaja,Luis R. Lopes,Nicola Migone,Stewart J. Payne,Rebecca C. Pollitt,Sue Povey,Cheryl K. Ridout,Rachel L. Robinson,Richard H Scott,Adam Shaw,Petros Syrris,Rohan Taylor,Anthony M. Vandersteen,Antoinette Amuzu,Juan P. Casas,John C. Chambers,George Dedoussis,Giovanni Gambaro,Paolo Gasparini,Aaron Isaacs,Jon Johnson,Marcus E. Kleber,Jaspal S. Kooner,Claudia Langenberg,Jian'an Luan,Giovanni Malerba,Winfried Maerz,Angela Matchan,Richard W Morris,Børge G. Nordestgaard,Marianne Benn,Robert A. Scott,Daniela Toniolo,Michela Traglia,Anne Tybjærg-Hansen,Cornelia M. van Duijn,Elisabeth M. van Leeuwen,Anette Varbo,Peter H. Whincup,Gianluigi Zaza,Weihua Zhang +241 more
TL;DR: The contribution of rare and low-frequency variants to human traits is largely unexplored as mentioned in this paper, but the contribution of these variants to the human traits has not yet been fully explored.
Journal ArticleDOI
Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population
Jordana T. Bell,Pei-Chien Tsai,Tsun-Po Yang,Ruth Pidsley,James Nisbet,Daniel Glass,Massimo Mangino,Guangju Zhai,Guangju Zhai,Feng Zhang,Ana M. Valdes,So-Youn Shin,Emma Dempster,Robin M. Murray,Elin Grundberg,Elin Grundberg,Åsa K. Hedman,Alexandra C. Nica,Kerrin S. Small,Emmanouil T. Dermitzakis,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Jonathan Mill,Tim D. Spector,Panos Deloukas +25 more
TL;DR: The results suggest that in a small set of genes DNA methylation may be a candidate mechanism of mediating not only environmental, but also genetic effects on age-related phenotypes, and that a-DMRs may initiate at an earlier age.
Journal ArticleDOI
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Anna Köttgen,Anna Köttgen,Eva Albrecht,Alexander Teumer,Veronique Vitart,Jan Krumsiek,Claudia Hundertmark,Giorgio Pistis,Daniela Ruggiero,Conall M. O'Seaghdha,Conall M. O'Seaghdha,Toomas Haller,Qiong Yang,Qiong Yang,Toshiko Tanaka,Andrew D. Johnson,Zoltán Kutalik,Zoltán Kutalik,Albert V. Smith,Julia Shi,Maksim Struchalin,Rita P. S. Middelberg,Morris J. Brown,Angelo L. Gaffo,Nicola Pirastu,Guo Li,Caroline Hayward,Tatijana Zemunik,Jennifer E. Huffman,Loic Yengo,Jing Hua Zhao,Ayse Demirkan,Mary F. Feitosa,Xuan Liu,Giovanni Malerba,Lorna M. Lopez,Pim van der Harst,Xinzhong Li,Marcus E. Kleber,Andrew A. Hicks,Ilja M. Nolte,Åsa Johansson,Federico Murgia,Sarah H. Wild,Stephan J. L. Bakker,John F. Peden,Abbas Dehghan,Maristella Steri,Albert Tenesa,Vasiliki Lagou,Perttu Salo,Massimo Mangino,Lynda M. Rose,Terho Lehtimäki,Owen M. Woodward,Yukinori Okada,Adrienne Tin,Christian Müller,Christopher Oldmeadow,Margus Putku,Darina Czamara,Peter Kraft,Laura Frogheri,Gian Andri Thun,Gian Andri Thun,Anne Grotevendt,Gauti Kjartan Gislason,Tamara B. Harris,Lenore J. Launer,Patrick F. McArdle,Alan R. Shuldiner,Eric Boerwinkle,Josef Coresh,Helena Schmidt,Michael Schallert,Nicholas G. Martin,Grant W. Montgomery,Michiaki Kubo,Yusuke Nakamura,Toshihiro Tanaka,Patricia B. Munroe,Nilesh J. Samani,Nilesh J. Samani,David R. Jacobs,Kiang Liu,Pio D'Adamo,Sheila Ulivi,Jerome I. Rotter,Bruce M. Psaty,Bruce M. Psaty,Peter Vollenweider,Gérard Waeber,Susan Campbell,Olivier Devuyst,Pau Navarro,Ivana Kolcic,Nicholas D. Hastie,Beverley Balkau,Philippe Froguel,Tõnu Esko,Andres Salumets,Kay-Tee Khaw,Claudia Langenberg,Nicholas J. Wareham,Aaron Isaacs,Aldi Kraja,Qunyuan Zhang,Qunyuan Zhang,Philipp S. Wild,Rodney J. Scott,Elizabeth G. Holliday,Elin Org,Margus Viigimaa,Stefania Bandinelli,Jeffrey Metter,Antonio Lupo,Elisabetta Trabetti,Rossella Sorice,Angela Döring,Eva Lattka,Konstantin Strauch,Fabian J. Theis,Melanie Waldenberger,H.-Erich Wichmann,Gail Davies,Alan J. Gow,Marcel Bruinenberg,Ronald P. Stolk,Jaspal S. Kooner,Jaspal S. Kooner,Weihua Zhang,Weihua Zhang,Bernhard R. Winkelmann,Bernhard O. Boehm,Susanne Lucae,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Johannes H. Smit,Gary C. Curhan,Poorva Mudgal,Poorva Mudgal,Robert M. Plenge,Robert M. Plenge,Laura Portas,Ivana Persico,Mirna Kirin,James F. Wilson,Irene Mateo Leach,Wiek H. van Gilst,Anuj Goel,Halit Ongen,Albert Hofman,Fernando Rivadeneira,André G. Uitterlinden,Medea Imboden,Medea Imboden,Arnold von Eckardstein,Francesco Cucca,Ramaiah Nagaraja,Maria Grazia Piras,Matthias Nauck,Claudia Schurmann,Kathrin Budde,Florian Ernst,Susan M. Farrington,Evropi Theodoratou,Inga Prokopenko,Michael Stumvoll,A. Jula,Markus Perola,Markus Perola,Markus Perola,Veikko Salomaa,So-Youn Shin,Tim D. Spector,Cinzia Sala,Paul M. Ridker,Mika Kähönen,Jorma Viikari,Christian Hengstenberg,Christopher P. Nelson,Christopher P. Nelson,James F. Meschia,Mike A. Nalls,Pankaj Sharma,Andrew B. Singleton,Naoyuki Kamatani,Tanja Zeller,Michel Burnier,John Attia,Maris Laan,Norman Klopp,Hans L. Hillege,Stefan Kloiber,Hyon K. Choi,Hyon K. Choi,Mario Pirastu,Silvia Tore,Nicole Probst-Hensch,Nicole Probst-Hensch,Henry Völzke,Vilmundur Gudnason,Afshin Parsa,Reinhold Schmidt,John Whitfield,Myriam Fornage,Paolo Gasparini,David S. Siscovick,Ozren Polasek,Harry Campbell,Igor Rudan,Igor Rudan,Nabila Bouatia-Naji,Andres Metspalu,Ruth J. F. Loos,Cornelia M. van Duijn,Ingrid B. Borecki,Luigi Ferrucci,Giovanni Gambaro,Ian J. Deary,Bruce H. R. Wolffenbuttel,John C. Chambers,John C. Chambers,Winfried März,Winfried März,Peter P. Pramstaller,Harold Snieder,Ulf Gyllensten,Alan F. Wright,Gerjan Navis,Hugh Watkins,Jacqueline C.M. Witteman,Serena Sanna,Sabine Schipf,Malcolm G. Dunlop,Anke Tönjes,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Nicole Soranzo,Daniela Toniolo,Daniel I. Chasman,Olli T. Raitakari,W. H. Linda Kao,Marina Ciullo,Caroline S. Fox,Caroline S. Fox,Mark J. Caulfield,Murielle Bochud,Christian Gieger +250 more
TL;DR: New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.