G
Gabriel Therizols
Researcher at University of Lyon
Publications - 12
Citations - 651
Gabriel Therizols is an academic researcher from University of Lyon. The author has contributed to research in topics: Ribosome & RNA. The author has an hindex of 8, co-authored 11 publications receiving 483 citations. Previous affiliations of Gabriel Therizols include University of California, San Francisco & French Institute of Health and Medical Research.
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Journal ArticleDOI
p53 Acts as a Safeguard of Translational Control by Regulating Fibrillarin and rRNA Methylation in Cancer
Virginie Marcel,Virginie Marcel,Sandra E. Ghayad,Sandra E. Ghayad,Stephane Belin,Stephane Belin,Gabriel Therizols,Gabriel Therizols,Anne Pierre Morel,Anne Pierre Morel,Eduardo Solano-Gonzàlez,Julie A. Vendrell,Sabine Hacot,Sabine Hacot,Hichem C. Mertani,Hichem C. Mertani,Marie Alexandra Albaret,Marie Alexandra Albaret,Jean-Christophe Bourdon,Lee B. Jordan,Alastair M. Thompson,Yasmine Tafer,Yasmine Tafer,Rong Cong,Philippe Bouvet,Jean Christophe Saurin,Jean Christophe Saurin,Frédéric Catez,Frédéric Catez,Anne-Catherine Prats,Alain Puisieux,Alain Puisieux,Jean-Jacques Diaz,Jean-Jacques Diaz +33 more
TL;DR: It is shown that p53 represses expression of the rRNA methyl-transferase fibrillarin (FBL) by binding directly to FBL, and acts as a safeguard of protein synthesis by regulating FBL and the subsequent quality and intrinsic activity of ribosomes.
Journal ArticleDOI
Evidence for rRNA 2'-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes.
Jenny Erales,Virginie Marchand,Baptiste Panthu,Baptiste Panthu,Sandra Gillot,Stephane Belin,Sandra E. Ghayad,Maxime Garcia,Florian Laforêts,Virginie Marcel,Agnès Baudin-Baillieu,Pierre Bertin,Yohann Couté,Annie Adrait,Melanie Meyer,Gabriel Therizols,Marat Yusupov,Olivier Namy,Théophile Ohlmann,Théophile Ohlmann,Yuri Motorin,Frédéric Catez,Jean-Jacques Diaz +22 more
TL;DR: It is revealed that ribosomal RNA 2′-O-methylation can be modulated in human ribosomes, including at key functional sites for translation, and that changes in the 2′'-O- methylation pattern control the intrinsic capabilities of ribosome to translate mRNAs.
Journal ArticleDOI
Nucleolar Localization of a Netrin-1 Isoform Enhances Tumor Cell Proliferation
Céline Delloye-Bourgeois,David Goldschneider,Andrea Paradisi,Gabriel Therizols,Stephane Belin,Sabine Hacot,Manuel Rosa-Calatrava,Jean-Yves Scoazec,Jean-Jacques Diaz,Agnès Bernet,Patrick Mehlen +10 more
TL;DR: It is shown that in contrast to full-length, secreted netrin-1, some cancer cells produced a truncated intranuclear form of netrin -1 that stimulates cell proliferation, potentially by enhancing ribosome biogenesis.
Journal ArticleDOI
Purification of ribosomes from human cell lines.
Stephane Belin,Stephane Belin,Sabine Hacot,Lionel Daudignon,Gabriel Therizols,Stéphane Pourpe,Hichem C. Mertani,Manuel Rosa-Calatrava,Jean-Jacques Diaz +8 more
TL;DR: The protocol described here is simple, efficient, and robust, and allows one to purify high‐quality ribosomes from human cultured cell lines, and is adequate for most of the subsequent analyses of their RNA and protein content.
Journal ArticleDOI
Deletion 6q Drives T-cell Leukemia Progression by Ribosome Modulation.
Stéphanie Gachet,Stéphanie Gachet,Tiama El-Chaar,Tiama El-Chaar,David Avran,David Avran,Eulàlia Genescà,Eulàlia Genescà,Frédéric Catez,Samuel Quentin,Samuel Quentin,Marc Delord,Gabriel Therizols,Delphine Briot,Delphine Briot,Godelieve Meunier,Godelieve Meunier,Lucie Hernandez,Lucie Hernandez,Marika Pla,Marika Pla,Willem K. Smits,Jessica G.C.A.M. Buijs-Gladdines,Wouter Van Loocke,Gerben Menschaert,Isabelle André-Schmutz,Tom Taghon,Pieter Van Vlierberghe,Jules P.P. Meijerink,André Baruchel,Hervé Dombret,Emmanuelle Clappier,Emmanuelle Clappier,Jean-Jacques Diaz,Claude Gazin,François Sigaux,François Sigaux,Jean Soulier,Jean Soulier +38 more
TL;DR: Combined genomic analysis and functional models show that the codeletion of two contiguous genes at 6q14 enhances malignancy through deregulation of a ribosome-mitochondria axis, suggesting the potential for therapeutic intervention.