F
Florian Laforêts
Researcher at University of Lyon
Publications - 12
Citations - 241
Florian Laforêts is an academic researcher from University of Lyon. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 3, co-authored 4 publications receiving 153 citations. Previous affiliations of Florian Laforêts include Claude Bernard University Lyon 1 & French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Evidence for rRNA 2'-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes.
Jenny Erales,Virginie Marchand,Baptiste Panthu,Baptiste Panthu,Sandra Gillot,Stephane Belin,Sandra E. Ghayad,Maxime Garcia,Florian Laforêts,Virginie Marcel,Agnès Baudin-Baillieu,Pierre Bertin,Yohann Couté,Annie Adrait,Melanie Meyer,Gabriel Therizols,Marat Yusupov,Olivier Namy,Théophile Ohlmann,Théophile Ohlmann,Yuri Motorin,Frédéric Catez,Jean-Jacques Diaz +22 more
TL;DR: It is revealed that ribosomal RNA 2′-O-methylation can be modulated in human ribosomes, including at key functional sites for translation, and that changes in the 2′'-O- methylation pattern control the intrinsic capabilities of ribosome to translate mRNAs.
Journal ArticleDOI
Translational reprogramming of colorectal cancer cells induced by 5-fluorouracil through a miRNA-dependent mechanism.
Zeina Bash-Imam,Gabriel Therizols,Anne Vincent,Florian Laforêts,Micaela Polay Espinoza,Nathalie Pion,Françoise Macari,Julie Pannequin,Alexandre David,Jean-Christophe Saurin,Hichem C. Mertani,Julien Textoris,Didier Auboeuf,Frédéric Catez,Nicole Dalla Venezia,Martin Dutertre,Virginie Marcel,Jean-Jacques Diaz +17 more
TL;DR: Findings indicate that 5-FU promotes a translational reprogramming leading to the increased translation of a subset of mRNAs that involves at least for some of them, miRNA-dependent mechanisms, which supports a still poorly evaluated role of translational control in drug response.
Journal ArticleDOI
Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance
Gabriel Therizols,Zeina Bash-Imam,Baptiste Panthu,Christelle Machon,Anne Vincent,Julie Ripoll,Sophie Nait-Slimane,Mounira Chalabi-Dchar,Angeline Gaucherot,Maxime Garcia,Florian Laforêts,Virginie Marcel,Jihane Boubaker-Vitre,Marie Monet,Céline Bouclier,Christophe Vanbelle,Guillaume Souahlia,Elise Berthel,Marie Alexandra Albaret,Hichem C. Mertani,Michelle Prudhomme,Martine Bertrand,Alexandre David,Jean-Christophe Saurin,Philippe Bouvet,Eric Rivals,Théophile Ohlmann,Jérôme Guitton,Nicole Dalla Venezia,Julie Pannequin,Frédéric Catez,Jean-Jacques Diaz +31 more
TL;DR: In this article , the authors show that 5-fluorouracil (5-FU) treatment leads to the production of fluorinated ribosomes exhibiting altered translational activities and that sustained translation of IGF-1R mRNA, which encodes one of the most potent cell survival effectors, promotes the survival of 5-FU-treated colorectal cancer cells.
Posted ContentDOI
Alteration of ribosome function upon 5-fluorouracil treatment favours cancer cell drug-tolerance
Gabriel Therizols,Zeina Bash-Imam,Zeina Bash-Imam,Baptiste Panthu,Baptiste Panthu,Christelle Machon,Anne Vincent,Anne Vincent,Sophie Nait-Slimane,Sophie Nait-Slimane,Maxime Garcia,Maxime Garcia,Mounira Chalabi-Dchar,Mounira Chalabi-Dchar,Florian Laforêts,Florian Laforêts,Virginie Marcel,Jihane Boubaker-Vitre,Guillaume Souahlia,Guillaume Souahlia,Marie-Alexandra Albaret,Marie-Alexandra Albaret,Hichem C. Mertani,Hichem C. Mertani,Michel Prudhomme,M. Bertrand,Jean-Christophe Saurin,Philippe Bouvet,Théophile Ohlmann,Jérôme Guitton,Jérôme Guitton,Nicole Dalla-Venezia,Julie Pannequin,Frédéric Catez,Jean-Jacques Diaz +34 more
TL;DR: It is demonstrated that “man-made” fluorinated ribosomes favour the drug-tolerant cellular phenotype by promoting translation of survival genes by unraveling translation regulation as a novel gene expression mechanism helping cells to survive a drug-challenge.
Book ChapterDOI
Ribosomal RNA Methylation and Cancer
Gabriel Therizols,Florian Laforêts,Virginie Marcel,Frédéric Catez,Philippe Bouvet,Jean-Jacques Diaz +5 more
TL;DR: The function of rRNA methylation is described in the context of the cancer process and represents a prototypic example playing a central role in the pathological process.