G
Gabriela Maria Guerra
Publications - 7
Citations - 342
Gabriela Maria Guerra is an academic researcher. The author has contributed to research in topics: Acquired immune system & Biology. The author has an hindex of 3, co-authored 4 publications receiving 92 citations.
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Journal ArticleDOI
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients.
Hector Rincon-Arevalo,Mira Choi,Ana Luisa Stefanski,Fabian Halleck,Ulrike Weber,Franziska Szelinski,Bernd Jahrsdörfer,Hubert Schrezenmeier,Carolin Ludwig,Arne Sattler,Katja Kotsch,Alexander Potekhin,Yidan Chen,Gerd R Burmester,Kai-Uwe Eckardt,Gabriela Maria Guerra,Pawel Durek,Frederik Heinrich,Marta Ferreira-Gomes,Andreas Radbruch,Klemens Budde,Andreia C. Lino,Mir-Farzin Mashreghi,Mir-Farzin Mashreghi,Eva Schrezenmeier,Thomas Dörner +25 more
TL;DR: In this article, the authors found that immunosuppression resulted in impaired protective immunity after mRNA vaccination, including Ig induction with corresponding generation of plasmablasts and memory B cells.
Journal ArticleDOI
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself.
Marta Ferreira-Gomes,Andrey Kruglov,Andrey Kruglov,Pawel Durek,Frederik Heinrich,Caroline Tizian,Gitta Anne Heinz,Anna Pascual-Reguant,Weijie Du,Ronja Mothes,Chaofan Fan,Stefan Frischbutter,Katharina Habenicht,Lisa Budzinski,Justus Ninnemann,Péter K. Jani,Gabriela Maria Guerra,Katrin Lehmann,Mareen Matz,Lennard Ostendorf,Lukas Heiberger,Hyun-Dong Chang,Sandy Bauherr,Marcus Maurer,Günther Schönrich,Martin Raftery,Tilmann Kallinich,Marcus A. Mall,Stefan Angermair,Sascha Treskatsch,Thomas Dörner,Victor M. Corman,Andreas Diefenbach,Hans-Dieter Volk,Hans-Dieter Volk,Sefer Elezkurtaj,Thomas Winkler,Jun Dong,Anja E. Hauser,Helena Radbruch,Mario Witkowski,Fritz Melchers,Andreas Radbruch,Mir-Farzin Mashreghi +43 more
TL;DR: In this article, a single cell level analysis of plasmablasts egressed into the blood to study the dynamics of adaptive immune response in COVID-19 patients requiring intensive care.
Journal ArticleDOI
Non-redundant functions of group 2 innate lymphoid cells
Katja J Jarick,Patrycja M Topczewska,Manuel O. Jakob,Hiroshi Yano,Mohammad Arifuzzaman,Xuemei Gao,Sotiria Boulekou,Vladislava Stokic-Trtica,Pierre S. Leclere,Alexandra Preußer,Zoe A Rompe,Anton Stamm,Amy Tsou,Coco Chu,F.R. Heinrich,Gabriela Maria Guerra,Pawel Durek,Andranik Ivanov,Dieter Beule,Sofia Helfrich,Claudia U. Duerr,Anja A. Kühl,Christina Stehle,Chiara Romagnani,Mir-Farzin Mashreghi,Andreas Diefenbach,David Artis,Christoph S.N. Klose +27 more
Posted ContentDOI
In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response
Marta Ferreira-Gomes,Andrey Kruglov,Pawel Durek,Frederik Heinrich,Caroline Tizian,Anne Heinz G,Pascual-Reguant A,Du W,Ronja Mothes,Fan C,Stefan Frischbutter,Katharina Habenicht,Lisa Budzinski,Justus Ninnemann,Péter K. Jani,Gabriela Maria Guerra,Katrin Lehmann,Mareen Matz,Lennard Ostendorf,Lukas Heiberger,H.-D. Chang,Sandy Bauherr,Marcus Maurer,Günther Schönrich,Martin Raftery,Tilmann Kallinich,Alexander Mall M,Stefan Angermair,Sascha Treskatsch,Thomas Dörner,Max Corman,Andreas Diefenbach,Hans-Dieter Volk,Sefer Elezkurtaj,Thomas Winkler,Dong J,Erika Hauser A,Helena Radbruch,Mario Witkowski,Fritz Melchers,Andreas Radbruch,Mir-Farzin Mashreghi +41 more
TL;DR: In severely affected COVID-19 patients SARS-CoV-2 triggers chronic immune reactions which are controlled by TGF-{beta}, with most of the activated B cells being no longer specific for the Sars-Cov-2 spike protein and its receptor binding domain, nor for nucleoprotein.
Posted ContentDOI
Impaired antigen-specific memory B cell and plasma cell responses including lack of specific IgG upon SARS-CoV-2 BNT162b2 vaccination among Kidney Transplant and Dialysis patients
Hector Rincon-Arevalo,Mira Choi,Ana-Luisa Stefanski,Fabian Halleck,Ulrike Weber,Franziska Szelinski,Bernd Jahrsdoerfer,Hubert Schrezenmeier,Carolin Ludwig,Arne Sattler,Katja Kotsch,Alexander Potekhin,Yidan Chen,Gerd R Burmester,Kai-Uwe Eckardt,Gabriela Maria Guerra,Pawel Durek,Frederik Heinrich,Marta Ferreira-Gomes,Andreas Radbruch,Klemens Budde,Andreia C. Lino,Mir-Farzin Mashreghi,Mir-Farzin Mashreghi,Eva Schrezenmeier,Thomas Doerner +25 more
TL;DR: In this article, BNT162b2 was used to boost the immune response of kidney transplant recipients and dialysis patients to immunosuppression, which resulted in diminished humoral response and impaired molecular B cell memory formation.