L
Lukas Heiberger
Researcher at Leibniz Association
Publications - 4
Citations - 156
Lukas Heiberger is an academic researcher from Leibniz Association. The author has contributed to research in topics: Antigen & Stromal cell. The author has an hindex of 3, co-authored 4 publications receiving 53 citations.
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Journal ArticleDOI
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself.
Marta Ferreira-Gomes,Andrey Kruglov,Andrey Kruglov,Pawel Durek,Frederik Heinrich,Caroline Tizian,Gitta Anne Heinz,Anna Pascual-Reguant,Weijie Du,Ronja Mothes,Chaofan Fan,Stefan Frischbutter,Katharina Habenicht,Lisa Budzinski,Justus Ninnemann,Péter K. Jani,Gabriela Maria Guerra,Katrin Lehmann,Mareen Matz,Lennard Ostendorf,Lukas Heiberger,Hyun-Dong Chang,Sandy Bauherr,Marcus Maurer,Günther Schönrich,Martin Raftery,Tilmann Kallinich,Marcus A. Mall,Stefan Angermair,Sascha Treskatsch,Thomas Dörner,Victor M. Corman,Andreas Diefenbach,Hans-Dieter Volk,Hans-Dieter Volk,Sefer Elezkurtaj,Thomas Winkler,Jun Dong,Anja E. Hauser,Helena Radbruch,Mario Witkowski,Fritz Melchers,Andreas Radbruch,Mir-Farzin Mashreghi +43 more
TL;DR: In this article, a single cell level analysis of plasmablasts egressed into the blood to study the dynamics of adaptive immune response in COVID-19 patients requiring intensive care.
Journal ArticleDOI
Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells.
Rebecca Cornelis,Stefanie Hahne,Adriano Taddeo,Georg Petkau,Darya Malko,Pawel Durek,Manja Thiem,Lukas Heiberger,Lena Peter,Elodie Mohr,Cora Klaeden,Koji Tokoyoda,Francesco Siracusa,Bimba F. Hoyer,Bimba F. Hoyer,Falk Hiepe,Falk Hiepe,Mir-Farzin Mashreghi,Fritz Melchers,Hyun-Dong Chang,Andreas Radbruch +20 more
TL;DR: Stromal-cell-contact-induced PI3K and APRIL-induced NF-κB signaling provide the necessary and complementary signals to maintain bone marrow memory plasma cells.
Posted ContentDOI
In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-β-dominated adaptive immune response
Marta Ferreira-Gomes,Andrey Kruglov,Pawel Durek,Frederik Heinrich,Caroline Tizian,Anne Heinz G,Pascual-Reguant A,Du W,Ronja Mothes,Fan C,Stefan Frischbutter,Katharina Habenicht,Lisa Budzinski,Justus Ninnemann,Péter K. Jani,Gabriela Maria Guerra,Katrin Lehmann,Mareen Matz,Lennard Ostendorf,Lukas Heiberger,H.-D. Chang,Sandy Bauherr,Marcus Maurer,Günther Schönrich,Martin Raftery,Tilmann Kallinich,Alexander Mall M,Stefan Angermair,Sascha Treskatsch,Thomas Dörner,Max Corman,Andreas Diefenbach,Hans-Dieter Volk,Sefer Elezkurtaj,Thomas Winkler,Dong J,Erika Hauser A,Helena Radbruch,Mario Witkowski,Fritz Melchers,Andreas Radbruch,Mir-Farzin Mashreghi +41 more
TL;DR: In severely affected COVID-19 patients SARS-CoV-2 triggers chronic immune reactions which are controlled by TGF-{beta}, with most of the activated B cells being no longer specific for the Sars-Cov-2 spike protein and its receptor binding domain, nor for nucleoprotein.
Posted ContentDOI
Stromal cell-contact dependent PI3K and APRIL induced NF-κB signaling complement each other to prevent mitochondrial- and endoplasmic reticulum stress induced cell death of bone marrow plasma cells
Rebecca Cornelis,Stefanie Hahne,Adriano Taddeo,Adriano Taddeo,Georg Petkau,Darya Malko,Pawel Durek,Manja Thiem,Lukas Heiberger,Elodie Mohr,Cora Klaeden,Koji Tokoyoda,Francesco Siracusa,Francesco Siracusa,Bimba F. Hoyer,Bimba F. Hoyer,Falk Hiepe,Falk Hiepe,Mir-Farzin Mashreghi,Fritz Melchers,Hyun-Dong Chang,Andreas Radbruch +21 more
TL;DR: Stromal cell-contact induced PI3K and APRIL-induced NF-κB signaling provide necessary and complementary signals to maintain bone marrow memory plasma cells.