F
Frederik Heinrich
Researcher at Charité
Publications - 13
Citations - 568
Frederik Heinrich is an academic researcher from Charité. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 6, co-authored 13 publications receiving 179 citations.
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Journal ArticleDOI
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients.
Hector Rincon-Arevalo,Mira Choi,Ana Luisa Stefanski,Fabian Halleck,Ulrike Weber,Franziska Szelinski,Bernd Jahrsdörfer,Hubert Schrezenmeier,Carolin Ludwig,Arne Sattler,Katja Kotsch,Alexander Potekhin,Yidan Chen,Gerd R Burmester,Kai-Uwe Eckardt,Gabriela Maria Guerra,Pawel Durek,Frederik Heinrich,Marta Ferreira-Gomes,Andreas Radbruch,Klemens Budde,Andreia C. Lino,Mir-Farzin Mashreghi,Mir-Farzin Mashreghi,Eva Schrezenmeier,Thomas Dörner +25 more
TL;DR: In this article, the authors found that immunosuppression resulted in impaired protective immunity after mRNA vaccination, including Ig induction with corresponding generation of plasmablasts and memory B cells.
Journal ArticleDOI
SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself.
Marta Ferreira-Gomes,Andrey Kruglov,Andrey Kruglov,Pawel Durek,Frederik Heinrich,Caroline Tizian,Gitta Anne Heinz,Anna Pascual-Reguant,Weijie Du,Ronja Mothes,Chaofan Fan,Stefan Frischbutter,Katharina Habenicht,Lisa Budzinski,Justus Ninnemann,Péter K. Jani,Gabriela Maria Guerra,Katrin Lehmann,Mareen Matz,Lennard Ostendorf,Lukas Heiberger,Hyun-Dong Chang,Sandy Bauherr,Marcus Maurer,Günther Schönrich,Martin Raftery,Tilmann Kallinich,Marcus A. Mall,Stefan Angermair,Sascha Treskatsch,Thomas Dörner,Victor M. Corman,Andreas Diefenbach,Hans-Dieter Volk,Hans-Dieter Volk,Sefer Elezkurtaj,Thomas Winkler,Jun Dong,Anja E. Hauser,Helena Radbruch,Mario Witkowski,Fritz Melchers,Andreas Radbruch,Mir-Farzin Mashreghi +43 more
TL;DR: In this article, a single cell level analysis of plasmablasts egressed into the blood to study the dynamics of adaptive immune response in COVID-19 patients requiring intensive care.
Journal ArticleDOI
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells
Mario Witkowski,Mario Witkowski,Caroline Tizian,Marta Ferreira-Gomes,Daniela Niemeyer,Daniela Niemeyer,Terry Jones,Terry Jones,Terry Jones,Frederik Heinrich,Stefan Frischbutter,Stefan Angermair,Thordis Hohnstein,Irene Mattiola,Philipp Nawrath,Sophie Mc Ewen,Silvia Zocche,Edoardo Viviano,Gitta Anne Heinz,Marcus Maurer,Uwe Kölsch,Robert Lorenz Chua,Tom Aschman,Christian Meisel,Josefine Radke,Birgit Sawitzki,Jobst Roehmel,Kristina Allers,V. Moos,Thomas Schneider,Leif G. Hanitsch,Marcus A. Mall,Christian Conrad,Helena Radbruch,Claudia U. Duerr,Joseph A. Trapani,Emanuela Marcenaro,Tilmann Kallinich,Victor M. Corman,Victor M. Corman,Florian Kurth,Leif E. Sander,Christian Drosten,Christian Drosten,Sascha Treskatsch,Pawel Durek,Andrey Kruglov,Andrey Kruglov,Andreas Radbruch,Mir-Farzin Mashreghi,Andreas Diefenbach,Andreas Diefenbach +51 more
TL;DR: In this article, the authors show that in severe SARS-CoV-2, natural killer (NK) cells show remarkable defects in virus control, cytokine production and cell-mediated cytotoxicity despite high expression of cytotoxic effector molecules.
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The IFN-γ-Inducible GTPase, Irga6, Protects Mice against Toxoplasma gondii but Not against Plasmodium berghei and Some Other Intracellular Pathogens.
Oliver Liesenfeld,Iana Parvanova,Jens Zerrahn,Seong-Ji Han,Frederik Heinrich,Melba Muñoz,Frank Kaiser,Toni Aebischer,Thorsten Buch,Ari Waisman,Gaby Reichmann,Olaf Utermöhlen,Esther von Stebut,Friederike D. von Loewenich,Christian Bogdan,Sabine Specht,Michael Saeftel,Achim Hoerauf,Maria M. Mota,Stephanie Könen-Waisman,Stefan H. E. Kaufmann,Jonathan C. Howard +21 more
TL;DR: The results implicate Irga6 in the control of infection with Toxoplasma gondii and further highlight the importance of the IRG system for resistance to this pathogen.
Journal ArticleDOI
Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues
Fabian Guendel,Michael Kofoed-Branzk,Konrad Gronke,Caroline Tizian,Mario Witkowski,Hung-Wei Cheng,Gitta Anne Heinz,Frederik Heinrich,Pawel Durek,Paula S. Norris,Carl F. Ware,Christiane Ruedl,Susanne Herold,Klaus Pfeffer,Thomas Hehlgans,Ari Waisman,Burkhard Becher,Anastasios D. Giannou,Sebastian Brachs,Karolina Ebert,Yakup Tanriver,Burkhard Ludewig,Mir-Farzin Mashreghi,Andrey Kruglov,Andreas Diefenbach +24 more
TL;DR: Using genome-wide single-cell transcriptional profiling of intestinal mononuclear phagocytes and multidimensional flow cytometry, it is found that CP- and ILF-associated CD11c+ cells were a transcriptionally distinct subset of intestinal cDCs, which are named CIA-DCs.