G
Geoffrey C. Gurtner
Researcher at Stanford University
Publications - 478
Citations - 32002
Geoffrey C. Gurtner is an academic researcher from Stanford University. The author has contributed to research in topics: Wound healing & Medicine. The author has an hindex of 76, co-authored 423 publications receiving 25985 citations. Previous affiliations of Geoffrey C. Gurtner include Duke University & York University.
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Journal ArticleDOI
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Daniel J. Ceradini,Anita R Kulkarni,Matthew J. Callaghan,Oren M. Tepper,Nicholas Bastidas,Mark E. Kleinman,Jennifer M. Capla,Robert D. Galiano,Jamie P. Levine,Geoffrey C. Gurtner +9 more
TL;DR: It is shown that SDF-1 gene expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells, resulting in selective in vivo expression of S DF-1 in ischemic tissue in direct proportion to reduced oxygen tension.
Journal ArticleDOI
Wound repair and regeneration
TL;DR: Knowing how organisms retain the ability to regenerate tissue throughout adult life might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century.
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Human skin wounds: a major and snowballing threat to public health and the economy.
Chandan K. Sen,Gayle M. Gordillo,Sashwati Roy,Robert S. Kirsner,Lynn Lambert,Thomas K. Hunt,Finn Gottrup,Geoffrey C. Gurtner,Michael T. Longaker +8 more
TL;DR: The immense economic and social impact of wounds in the authors' society calls for allocation of a higher level of attention and resources to understand biological mechanisms underlying cutaneous wound complications.
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Human Endothelial Progenitor Cells From Type II Diabetics Exhibit Impaired Proliferation, Adhesion, and Incorporation Into Vascular Structures
Oren M. Tepper,Robert D. Galiano,Jennifer M. Capla,Christoph Kalka,Paul J. Gagne,Glen R. Jacobowitz,Jamie P. Levine,Geoffrey C. Gurtner +7 more
TL;DR: It is suggested that type II diabetes may alter EPC biology in processes critical for new blood vessel growth and may identify a population at high risk for morbidity and mortality after vascular occlusive events.
Journal ArticleDOI
Wound Healing: A Cellular Perspective.
TL;DR: It is shown that changes in the microenvironment including alterations in mechanical forces, oxygen levels, chemokines, extracellular matrix and growth factor synthesis directly impact cellular recruitment and activation, leading to impaired states of wound healing.