G
Geoffrey L. Chupp
Researcher at Yale University
Publications - 72
Citations - 6831
Geoffrey L. Chupp is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Asthma. The author has an hindex of 29, co-authored 42 publications receiving 6263 citations. Previous affiliations of Geoffrey L. Chupp include Boston University.
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Journal ArticleDOI
Asthma: Mechanisms of Disease Persistence and Progression
TL;DR: Human and animal data are reviewed detailing the cellular and molecular interactions in established allergic asthma that promote persistent disease, amplify inflammation, and, in turn, cause disease progression.
Journal ArticleDOI
Airway remodeling in asthma.
TL;DR: The prevalence, morbidity, and mortality of asthma have increased since the 1980s, and is the most frequent reason for preventable childhood hospitalizations in the United States.
Journal ArticleDOI
A Chitinase-like Protein in the Lung and Circulation of Patients with Severe Asthma
Geoffrey L. Chupp,Chun Geun Lee,Nizar N. Jarjour,Yun M. Shim,Carole Holm,Susan He,James Dziura,Jennifer L. Reed,Anthony J. Coyle,Peter A. Kiener,Mark R. Cullen,Martine Grandsaigne,Marie-Christine Dombret,Michel Aubier,Marina Pretolani,Jack A. Elias +15 more
TL;DR: YKL-40 is found in increased quantities in the serum and lungs in a subgroup of patients with asthma, in whom expression of chitinase in both compartments correlates with the severity of asthma.
Journal ArticleDOI
Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis.
Joseph Keane,M K Balcewicz-Sablinska,Heinz G. Remold,Geoffrey L. Chupp,B B Meek,Matthew J. Fenton,Hardy Kornfeld +6 more
TL;DR: The effect of Mycobacterium tuberculosis infection on the viability of healthy (control) human alveolar macrophages was evaluated by staining with ethidium homodimer and calcein to discriminate live from dead cells.
Journal ArticleDOI
Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function
Carole Ober,Zheng Tan,Ying Sun,Jennifer D. Possick,Lin Pan,Raluca Nicolae,Sadie Radford,Rodney Parry,Andrea Heinzmann,Klaus A. Deichmann,Lucille A. Lester,James E. Gern,Robert F. Lemanske,Dan L. Nicolae,Jack A. Elias,Geoffrey L. Chupp +15 more
TL;DR: CHI3L1 is a susceptibility gene for asthma, bronchial hyperresponsiveness, and reduced lung function, and elevated circulating YKL-40 levels are a biomarker for asthma and decline in lung function.