G
Geoffrey L. Chupp
Researcher at Yale University
Publications - 72
Citations - 6831
Geoffrey L. Chupp is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Asthma. The author has an hindex of 29, co-authored 42 publications receiving 6263 citations. Previous affiliations of Geoffrey L. Chupp include Boston University.
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Journal ArticleDOI
IL-18 Is Induced and IL-18 Receptor α Plays a Critical Role in the Pathogenesis of Cigarette Smoke-Induced Pulmonary Emphysema and Inflammation
Min-Jong Kang,Robert J. Homer,Amy Gallo,Chun Geun Lee,Kristina Crothers,Soo Jung Cho,Carolyn L. Rochester,Hilary Cain,Geoffrey L. Chupp,Ho Joo Yoon,Jack A. Elias +10 more
TL;DR: IL-18 and the IL-18 pathway are activated in CS-exposed mice and man, and it is demonstrated that IL- 18R signaling plays a critical role in the pathogenesis of CS-induced inflammation and emphysema.
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Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin.
Gerard J. Nau,Gerard J. Nau,Lucy Liaw,Geoffrey L. Chupp,Jeffrey S. Berman,Jeffrey S. Berman,Brigid L.M. Hogan,Richard A. Young +7 more
TL;DR: Results indicate that osteopontin augments the host response against a mycob bacterial infection and that it acts independently from other antimycobacterial resistance mechanisms.
Journal ArticleDOI
Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood
Unnur S. Bjornsdottir,Stephen T. Holgate,Padmalatha S. Reddy,Andrew A. Hill,Charlotte Marie McKee,Cristina Ileana Csimma,Amy A Weaver,Holly M. Legault,Clayton Small,Renee Ramsey,Debra K. Ellis,Conor Burke,Philip J. Thompson,Peter H. Howarth,Andrew J. Wardlaw,Phillip G. Bardin,David I. Bernstein,Louis Irving,Geoffrey L. Chupp,George W. Bensch,Gregory W. Bensch,Jon E. Stahlman,Monroe Karetzky,James W. Baker,Rachel L. Miller,Brad H. Goodman,Donald G. Raible,Samuel J. Goldman,Douglas K. Miller,John Louis Ryan,Andrew J. Dorner,Immermann Frederick,Margot O'Toole +32 more
TL;DR: This study has shown that analysis of PBMCs reveals systemic changes accompanying asthma exacerbation and has laid the foundation for future comparative studies usingPBMCs.
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Transgenic modeling of transforming growth factor-beta(1): role of apoptosis in fibrosis and alveolar remodeling.
TL;DR: An IL-13-TGF-beta(1) pathway of tissue remodeling that regulates inflammation, mucus metaplasia, apoptosis, vascular responses, and fibrosis in the lung is defined and sites at which therapies can be directed to control these important responses are highlighted.
Journal ArticleDOI
The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases
Carole Ober,Geoffrey L. Chupp +1 more
TL;DR: These genes represent novel asthma susceptibility genes that influence chitotriosidase enzyme activity, acid mammalian chitinase activity, and YKL-40 levels, respectively.