Georg N. Duda

TL;DR: Chip-based whole-genome gene expression analyses of fracture hematoma tissue revealed an association with extracellular space, cell migration or vasculature development and observed an interaction of age and mechanical stimuli in vitro on cell migration of mesenchymal stromal cells.

TL;DR: A small animal model for bone defect healing is established which allows modeling the mechanical conditions at the defect site in a defined manner and no difference was found between the groups regarding complication rate.

TL;DR: It is hypothesized that the re‐design of existing implant designs can result in further reduction of strain shielding and thus keep bone loss minimal following total hip replacement and investigates whether strain shielding can be avoided by changing implant shape and/or material properties.

TL;DR: Graft osteoconductive properties and scaffold-surface guided extracellular matrix deposition are found to be essential features driving bone defect filling in a 3D-printed honeycomb titanium structure, paving the way for the design of more effective 3D scaffold structures and their pre-clinical optimization, prior to their application in scaffolds-based bone defect regeneration.

TL;DR: A 3D nonlinear poroelastic finite element model model study of a lumbar motion segment L4-L5 was performed to predict the temporal shear response under various single and combined shear loads, indicating satisfactory agreement on anterior displacement and stiffness response.