Georg N. Duda

TL;DR: This study is the first to demonstrate that microstructure and strut homogeneity influence callus stiffness and strength.

TL;DR: It is demonstrated that already small changes in duration or frequency of mechanical stimulation had significant consequences for the behavior of osteoblast- and osteoclast-like cells in co-culture, which partially depend on the differentiation status of the osteoc last cells.

TL;DR: The concept that disease-deduced growth factor variants are promising lead structures for novel therapeutics with improved clinical activities is supported, as microCT and histological analyses indicate that GDF5(N445T)-treated defects show faster and more efficient healing compared to GDF 5 wild type (GDF5 (wt))-treated defects.

TL;DR: Wang et al. as discussed by the authors used 3D small-angle X-ray scattering (3D SAXS) to study the structural characteristics of bone callus and found that the plate shaped mineral particles in the healing callus were aligned in groups with their predominant orientations occurring as a fiber texture.

TL;DR: The data suggest that, during growth and skeletal maturation, the response of bone to mechanical loading is a deposition of new bone matrix, where the tissue amount but not its mineral or elastic properties are influenced by animal age.