Georg N. Duda

TL;DR: Mechanical loading further enhanced the efficacy of BMP2 application evidenced by increased mineralized tissue volume and mineralization at the stage of bony callus bridging, suggesting that already a minimal amount of mechanical stimulation through load bearing or exercise may be a promising adjunct stimulus to enhance the effectiveness of cytokine treatment in segmental defects.

TL;DR: Although recuperation seems to allow a certain recovery of iron storage, particularly in athletes with initially low ferritin levels, this retrieval was insufficient to fully normalise reduced iron levels, Therefore, iron status should be carefully monitored during the various training and competitive periods in elite athletes.

TL;DR: With rapid advances occurring in imaging modalities and methods to characterize tissue properties, new opportunities exist to better understand the role of mechanics in the biology of bone regeneration.

TL;DR: Comparison of interbody fusion achieved using an autologous tricortical iliac crest bone graft with those of a cylinder- and a box-design cage in a sheep cervical spine model revealed significantly lower residual flexion-extension movement in sheep with the cylinder cage-fixed spines than in those that received bone graft group.

TL;DR: A polymer-based scaffold that can be loaded with cells and growth factors and inserted directly into a bone defect, with healing demonstrated in sheep after only 3 months, is designed and put to the test for evaluation of bone regeneration and load bearing in humans.