Georg N. Duda

TL;DR: A simple theoretical model is used to investigate cellular and matrix organization as a result of mechanical feedback signals between cells and the surrounding ECM and shows that a group of contractile cells will self-polarize at a large scale, even in homogeneous environments.

TL;DR: The reduced range of active tibiofemoral translation suggests overloading of the passive structures in passively lax knees, either through excessive muscular action or joint subluxation, and could provide a plausible mechanism for explaining posttraumatic degeneration of cartilage in the joint.

TL;DR: The presented method allows simulation of cell and tissue differentiation during the early phase of fracture healing using a mixed construct composed of lyophilized cancellous bone and a fibrin matrix in a sandwich configuration to serve as an in vitro model for the examination of mechanical and pharmacological influences during theEarly phase of bone healing on a cellular level.

TL;DR: It is concluded that in vitro aging rather than in vivo donor aging influences BMSC characteristics, and BMSCs from both cohorts meet the standard criteria for MSC, exhibiting similar morphology, growth kinetics, gene expression profiles, and pro-angiogenic and immunosuppressive potential.

TL;DR: A direct effect of mechanical stimuli on osteoblast-like cells as well as on osteoclast formation and activity in vitro is demonstrated, demonstrating the necessity to investigate the effect of the same stimulation parameter on the co-culture of both cell types.