G
George W. Nelson
Researcher at Leidos
Publications - 84
Citations - 14306
George W. Nelson is an academic researcher from Leidos. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 44, co-authored 82 publications receiving 13204 citations. Previous affiliations of George W. Nelson include Science Applications International Corporation & National Institutes of Health.
Papers
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Journal ArticleDOI
Modulating influence on HIV/AIDS by interacting RANTES gene variants.
Ping An,George W. Nelson,Lihua Wang,Sharyne Donfield,James J. Goedert,John P. Phair,David Vlahov,Susan Buchbinder,William L. Farrar,William S. Modi,Stephen J. O'Brien,Cheryl A. Winkler +11 more
TL;DR: The diminished transcription of RANTES afforded by the In1.1C regulatory allele is consistent with increased HIV-1 spread in vivo, leading to accelerated progression to AIDS.
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Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans
Barry I. Freedman,Pamela J. Hicks,Meredith A. Bostrom,Mary E. Cunningham,Yongmei Liu,Jasmin Divers,Jeffrey B. Kopp,Cheryl A. Winkler,George W. Nelson,Carl D. Langefeld,Donald W. Bowden +10 more
TL;DR: The study shows that gene-environment and/or gene-gene interactions may initiate kidney disease in genetically susceptible individuals, because African Americans homozygous for MYH9 risk alleles do not universally develop kidney disease.
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APOL1 kidney risk alleles: population genetics and disease associations.
TL;DR: An update on the spectrum of APOL1 kidney disease and on the worldwide distribution of these kidney risk variants is provided and the proper way to run a recessive analysis on joint and independent effects is summarized.
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Evaluation of nonviral risk factors for nasopharyngeal carcinoma in a high‐risk population of Southern China
Xiuchan Guo,Randall C. Johnson,Hong Deng,Jian Liao,Li Guan,George W. Nelson,Mingzhong Tang,Yuming Zheng,Stephen J. O'Brien,Cheryl A. Winkler,Yi Zeng +10 more
TL;DR: A case‐control study in Guangxi Province of Southern China in 2004–2005 assessed the contribution of EBV/IgA/VCA antibody serostatus to NPC risk—32.2% of NPC can be explained by IgA+ status, however, family history and environmental risk factors cumulatively explained only 2.7% of NPCs development in NPC high risk population.
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Effects of human TRIM5α polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection
Hassan Javanbakht,Ping An,Bert Gold,Desiree C. Petersen,Colm O'hUigin,George W. Nelson,Stephen J. O'Brien,Gregory D. Kirk,Roger Detels,Susan Buchbinder,Sharyne Donfield,Sergey Shulenin,Byeongwoon Song,Michel Perron,Matthew Stremlau,Joseph Sodroski,Michael Dean,Cheryl A. Winkler +17 more
TL;DR: Polymorphism in human TRIM5 may influence susceptibility to HIV-1 infection, a possibility that merits additional evaluation in independent cohorts.